2024-03-29T15:07:15Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/95302023-10-05T14:17:58Zcom_20.500.12105_2060com_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_2061
Repisalud
author
Manzano-Román, Raúl
author
Sánchez-Ovejero, Carlos
author
Hernandez-Gonzalez, Ana
author
Casulli, Adriano
author
Siles-Lucas, Mar
funder
Unión Europea. Comisión Europea. 7 Programa Marco
2020-04-13T12:36:21Z
2020-04-13T12:36:21Z
2015
Biomed Res Int. 2015;2015:428205.
2314-6133
http://hdl.handle.net/20.500.12105/9530
26504805
10.1155/2015/428205
2314-6141
BioMed research international
Cystic echinococcosis (CE) is an important helminthic zoonotic disease caused by the Echinococcus granulosus complex. In humans, CE is a chronic disease driven by the growth of echinococcal cysts in different organs. Prognosis of this disease depends on multiple factors, including location, number, size, and stage of the cysts, making CE a disease of complex management. CE is usually asymptomatic for years and attracts limited attention from funding organizations and health authorities. For this reason, only experts' recommendations are available but no evidence-based conclusions have been drawn for CE clinical management. One of those pitfalls refers to the lack of evidence to support the use of serological tools for the diagnosis and follow-up of CE patients. In this respect, crude antigens are used to detect specific antibodies in patients, giving rise to false positive results. The advent of molecular techniques allowing the production of recombinant proteins has provided a number of candidate antigens that could overcome the problems associated with the use of crude parasite extracts in the serological assays. In this review, we present the last advances in this field, proposing the use of serology to support cyst stage-specific diagnosis and follow-up.
eng
Serological Diagnosis and Follow-Up of Human Cystic Echinococcosis: A New Hope for the Future?
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/9530/1/SerologicalDiagnosisAndFollow_2015.pdf
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SerologicalDiagnosisAndFollow_2015.pdf
URL
https://repisalud.isciii.es/bitstream/20.500.12105/9530/3/SerologicalDiagnosisAndFollow_2015.pdf.txt
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SerologicalDiagnosisAndFollow_2015.pdf.txt