2024-03-28T20:29:43Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/95282022-10-13T08:04:23Zcom_20.500.12105_2102com_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_2103
Repisalud
author
Posada De la Paz, Manuel
author
Philen, Rossanne M
author
Gerr, Fredric
author
Letz, Richard
author
Ferrari Arroyo, Maria José
author
Vela, Lydia
author
Izquierdo Martinez, Maravillas
author
Martin Arribas, Maria Concepcion
author
Abaitua-Borda, Ignacio
author
Ramos, Alejandro
author
Mora, Cristina
author
Matesanz, Gloria
author
Roldán, Maria Teresa
author
Pareja, Juan
funder
World Health Organization (WHO/OMS)
2020-04-13T12:21:38Z
2020-04-13T12:21:38Z
2003-08
Environ Health Perspect. 2003 Aug;111(10):1326-34.
0091-6765
http://hdl.handle.net/20.500.12105/9528
12896854
10.1289/ehp.111-1241614
Environmental health perspectives
Toxic oil syndrome (TOS) resulted from consumption of rapeseed oil denatured with 2% aniline and affected more than 20,000 persons. Eighteen years after the epidemic, many patients continue to report neurologic symptoms that are difficult to evaluate using conventional techniques. We conducted an epidemiologic study to determine whether an exposure to toxic oil 18 years ago was associated with current adverse neurobehavioral effects. We studied a case group of 80 adults exposed to toxic oil 18 years ago and a referent group of 79 adult age- and sex-frequency-matched unexposed subjects. We interviewed subjects for demographics, health status, exposures to neurotoxicants, and responses to the Kaufman Brief Intelligence Test (K-BIT), Programa Integrado de Exploracion Neuropsicologica (PIEN), and Goldberg depression questionnaires and administered quantitative neurobehavioral and neurophysiologic tests by computer or trained nurses. The groups did not differ with respect to educational background or other critical variables. We examined associations between case and referent groups and the neurobehavioral and neurophysiologic outcomes of interest. Decreased distal strength of the dominant and nondominant hands and increased vibrotactile thresholds of the fingers and toes were significantly associated with exposure to toxic oil. Finger tapping, simple reaction time latency, sequence B latency, symbol digit latency, and auditory digit span were also significantly associated with exposure. Case subjects also had statistically significantly more neuropsychologic symptoms compared with referents. Using quantitative neurologic tests, we found significant adverse central and peripheral neurologic effects in a group of TOS patients 18 years after exposure to toxic oil when compared with a nonexposed referent group. These effects were not documented by standard clinical examination and were found more frequently in women.
eng
Neurologic outcomes of toxic oil syndrome patients 18 years after the epidemic
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/9528/1/NeurologicOutcomesOfToxic_2003.pdf
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/9528/3/NeurologicOutcomesOfToxic_2003.pdf.txt
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NeurologicOutcomesOfToxic_2003.pdf.txt