2024-03-28T14:02:52Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/92552022-10-25T11:10:26Zcom_20.500.12105_2060com_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_2061
Repisalud
author
Sliepen, Kwinten
author
Han, Byung Woo
author
Bontjer, Ilja
author
Mooij, Petra
author
Garces, Fernando
author
Behrens, Anna-Janina
author
Rantalainen, Kimmo
author
Kumar, Sonu
author
Sarkar, Anita
author
Brouwer, Philip J M
author
Hua, Yuanzi
author
Tolazzi, Monica
author
Schermer, Edith
author
Torres, Jonathan L
author
Ozorowski, Gabriel
author
van der Woude, Patricia
author
de la Peña, Alba Torrents
author
van Breemen, Mariëlle J
author
Camacho-Sánchez, Juan Miguel
author
Burger, Judith A
author
Medina-Ramírez, Max
author
Gonzalez-Fernandez, Nuria
author
Alcamí, José
author
LaBranche, Celia
author
Scarlatti, Gabriella
author
van Gils, Marit J
author
Crispin, Max
author
Montefiori, David C
author
Ward, Andrew B
author
Koopman, Gerrit
author
Moore, John P
author
Shattock, Robin J
author
Bogers, Willy M
author
Wilson, Ian A
author
Sanders, Rogier W
funder
Unión Europea
funder
Instituto de Salud Carlos III
2020-03-17T08:49:20Z
2020-03-17T08:49:20Z
2019
Nat Commun. 2019 May 29;10(1):2355
2041-1723
http://hdl.handle.net/20.500.12105/9255
31142746
10.1038/s41467-019-10262-5
2041-1723
Nature communications
Stabilized HIV-1 envelope glycoproteins (Env) that resemble the native Env are utilized in vaccination strategies aimed at inducing broadly neutralizing antibodies (bNAbs). To limit the exposure of rare isolate-specific antigenic residues/determinants we generated a SOSIP trimer based on a consensus sequence of all HIV-1 group M isolates (ConM). The ConM trimer displays the epitopes of most known bNAbs and several germline bNAb precursors. The crystal structure of the ConM trimer at 3.9 Å resolution resembles that of the native Env trimer and its antigenic surface displays few rare residues. The ConM trimer elicits strong NAb responses against the autologous virus in rabbits and macaques that are significantly enhanced when it is presented on ferritin nanoparticles. The dominant NAb specificity is directed against an epitope at or close to the trimer apex. Immunogens based on consensus sequences might have utility in engineering vaccines against HIV-1 and other viruses.
eng
Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/9255/1/StructureAndImmunogenicityOf_2019.pdf
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https://repisalud.isciii.es/bitstream/20.500.12105/9255/3/StructureAndImmunogenicityOf_2019.pdf.txt
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StructureAndImmunogenicityOf_2019.pdf.txt