2024-03-28T14:23:45Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/91622022-09-14T11:13:40Zcom_20.500.12105_2174com_20.500.12105_2051com_20.500.12105_2173col_20.500.12105_2175
Repisalud
author
Carmona-Bayonas, Alberto
author
Jiménez-Fonseca, Paula
author
Lamarca, Ángela
author
Barriuso, Jorge
author
Castaño, Ángel
author
Benavent, Marta
author
Alonso, Vicente
author
Riesco-Martínez, María Del Carmen
author
Alonso-Gordoa, Teresa
author
Custodio, Ana
author
Sánchez Cánovas, Manuel
author
Hernando Cubero, Jorge
author
López, Carlos
author
Lacasta, Adelaida
author
Fernández Montes, Ana
author
Marazuela, Mónica
author
Crespo, Guillermo
author
Escudero, Pilar
author
Diaz, José Ángel
author
Feliciangeli, Eduardo
author
Gallego, Javier
author
Llanos, Marta
author
Segura, Ángel
author
Vilardell, Felip
author
Percovich, Juan Carlos
author
Grande, Enrique
author
Capdevila, Jaume
author
Valle, Juan W
author
García-Carbonero, Rocio
funder
Novartis Farmaceútica
2020-03-02T09:32:36Z
2020-03-02T09:32:36Z
2019-10-01
J Clin Oncol. 2019 ;37(28):2571-2580.
0732-183X
http://hdl.handle.net/20.500.12105/9162
31390276
10.1200/JCO.19.00980
1527-7755
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
PURPOSE: Somatostatin analogs (SSAs) are recommended for the first-line treatment of most patients with well-differentiated, gastroenteropancreatic (GEP) neuroendocrine tumors; however, benefit from treatment is heterogeneous. The aim of the current study was to develop and validate a progression-free survival (PFS) prediction model in SSA-treated patients. PATIENTS AND METHODS: We extracted data from the Spanish Group of Neuroendocrine and Endocrine Tumors Registry (R-GETNE). Patient eligibility criteria included GEP primary, Ki-67 of 20% or less, and first-line SSA monotherapy for advanced disease. An accelerated failure time model was developed to predict PFS, which was represented as a nomogram and an online calculator. The nomogram was externally validated in an independent series of consecutive eligible patients (The Christie NHS Foundation Trust, Manchester, United Kingdom). RESULTS: We recruited 535 patients (R-GETNE, n = 438; Manchester, n = 97). Median PFS and overall survival in the derivation cohort were 28.7 (95% CI, 23.8 to 31.1) and 85.9 months (95% CI, 71.5 to 96.7 months), respectively. Nine covariates significantly associated with PFS were primary tumor location, Ki-67 percentage, neutrophil-to-lymphocyte ratio, alkaline phosphatase, extent of liver involvement, presence of bone and peritoneal metastases, documented progression status, and the presence of symptoms when initiating SSA. The GETNE-TRASGU (Treated With Analog of Somatostatin in Gastroenteropancreatic and Unknown Primary NETs) model demonstrated suitable calibration, as well as fair discrimination ability with a C-index value of 0.714 (95% CI, 0.680 to 0.747) and 0.732 (95% CI, 0.658 to 0.806) in the derivation and validation series, respectively. CONCLUSION: The GETNE-TRASGU evidence-based prognostic tool stratifies patients with GEP neuroendocrine tumors receiving SSA treatment according to their estimated PFS. This nomogram may be useful when stratifying patients with neuroendocrine tumors in future trials. Furthermore, it could be a valuable tool for making treatment decisions in daily clinical practice.
eng
PROGNOSTIC-FACTORS
NEOPLASMS
EVEROLIMUS
SUNITINIB
REGISTRY
THERAPY
MODEL
Prediction of Progression-Free Survival in Patients With Advanced, Well-Differentiated, Neuroendocrine Tumors Being Treated With a Somatostatin Analog: The GETNE-TRASGU Study
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/9162/1/predictionofprogression-free_2019.pdf
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https://repisalud.isciii.es/bitstream/20.500.12105/9162/5/predictionofprogression-free_2019.pdf.txt
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