2024-03-29T11:42:10Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/91432022-10-25T11:12:39Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2060com_20.500.12105_2052col_20.500.12105_16978col_20.500.12105_2061
Repisalud
author
Alvaro-Meca, Alejandro
author
Ryan, Pablo
author
Micheloud, Dariela
author
De Miguel, Angel
author
Berenguer, Juan
author
Resino, Salvador
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2020-02-25T09:50:22Z
2020-02-25T09:50:22Z
2018
Sci Rep. 2018 Aug 14;8(1):12137.
2045-2322
http://hdl.handle.net/20.500.12105/9143
30108235
10.1038/s41598-018-29739-2
2045-2322
Scientific reports
Chronic infections are a major factor in the development of pulmonary embolism (PE). We aimed to evaluate the trends of PE-related hospitalizations and PE-related deaths in people living with HIV (PLWH) during the era of combination antiretroviral therapy (cART) through a retrospective study in Spain. Data were collected from the Minimum Basic Data Set (MBDS) between 1997 and 2013. The study period was fragmented into four calendar periods (1997-1999, 2000-2003, 2004-2007, and 2008-2013). The rate of PE-related hospitalizations remained stable in PLWH (P = 0.361). HIV-monoinfected patients had a higher incidence than HIV/HCV-coinfected patients during all follow-up [(98.7 (95%CI = 92.2; 105.1); P < 0.001], but PE incidence decreased in HIV-monoinfected patients (P < 0.001) and increased in HIV/HCV-coinfected patients (P < 0.001). Concretely, the rate of PE-related hospitalizations decreased significantly in patients monoinfected with HIV [from 203.6 (95%CI = 175.7; 231.6) events per 100,000 patient-years in 1997-1999 to 74.3 (95%CI = 66.1; 82.3) in 2008-2013; P < 0.001], while patients coinfected with HIV/HCV had a significant increase [from 16.3 (95%CI = 11; 21.6) in 1997-1999 to 53.3 (95%CI = 45.9; 60.6) in 2008-2013; P < 0.001]. The mortality rate of PE-related hospitalizations showed a similar trend as PE incidence. In conclusion, the epidemiological trends of PE in PLWH changed during the cART era, with decreases in incidence and mortality in HIV-monoinfected and increases in both variables in patients coinfected with HIV/HCV.
eng
Trends in pulmonary embolism in patients infected with HIV during the combination antiretroviral therapy era in Spain: A nationwide population-based study
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/9143/1/TrendsInPulmonaryEmbolism_2018.pdf
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TrendsInPulmonaryEmbolism_2018.pdf
URL
https://repisalud.isciii.es/bitstream/20.500.12105/9143/3/TrendsInPulmonaryEmbolism_2018.pdf.txt
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TrendsInPulmonaryEmbolism_2018.pdf.txt