2024-03-28T21:48:47Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/89642022-11-07T10:07:38Zcom_20.500.12105_2060com_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_2061
Repisalud
author
Echevarria, Juan Emilio
author
Banyard, Ashley C
author
McElhinney, Lorraine M
author
Fooks, Anthony R
funder
Unión Europea. Comisión Europea. H2020
funder
Ministerio de Ciencia, Innovación y Universidades (España)
2020-01-29T11:44:59Z
2020-01-29T11:44:59Z
2019-09-24
Viruses. 2019 Sep 24;11(10). pii: E892.
1999-4915
http://hdl.handle.net/20.500.12105/8964
31554170
10.3390/v11100892
1999-4915
Viruses
The use of the rabies vaccine for post-exposure prophylaxis started as early as 1885, revealing a safe and efficient tool to prevent human rabies cases. Preventive vaccination is the basis for the control of canine-mediated rabies, which has already been eliminated from extensive parts of the world, including Europe. Plans to eliminate canine-mediated human rabies by 2030 have been agreed upon by international organisations. However, rabies vaccines are not efficacious against some divergent lyssaviruses. The presence in European indigenous bats of recently described lyssaviruses, which are not neutralised by antibody responses to existing vaccines, as well as the declaration of an imported case of an African lyssavirus, which also escapes vaccine-derived protection, leaves the European health authorities unable to provide efficacious protective vaccines to some potential situations of human exposure. All these circumstances highlight the need for a universal pan-lyssavirus rabies vaccine, able to prevent human rabies in all circumstances.
eng
Bat
Lyssavirus
Rabies
Vaccine
Current Rabies Vaccines Do Not Confer Protective Immunity against Divergent Lyssaviruses Circulating in Europe
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/8964/1/CurrentRabiesVaccinesDo_2019.pdf
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CurrentRabiesVaccinesDo_2019.pdf
URL
https://repisalud.isciii.es/bitstream/20.500.12105/8964/5/CurrentRabiesVaccinesDo_2019.pdf.txt
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CurrentRabiesVaccinesDo_2019.pdf.txt