2024-03-29T05:26:17Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/87492022-11-10T11:03:15Zcom_20.500.12105_2060com_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_2061
Repisalud
author
Martín-Díaz, Ariadna
author
Rubio Muñoz, Jose Miguel
author
Herrero-Martínez, Juan María
author
Lizasoain, Manolo
author
Ruiz-Giardin, José Manuel
author
Jaqueti, Jerónimo
author
Cuadros, Juan
author
Rojo-Marcos, Gerardo
author
Martín-Rabadán, Pablo
author
Calderón, María
author
Campelo, Carolina
author
Velasco, María
author
Pérez-Ayala, Ana
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2019-12-05T12:10:14Z
2019-12-05T12:10:14Z
2018-08-29
Malar J. 2018 Aug 29;17(1):314.
1475-2875
http://hdl.handle.net/20.500.12105/8749
30157862
10.1186/s12936-018-2459-2
1475-2875
Malaria journal
BACKGROUND: Malaria is currently the most important human parasitic disease in the world responsible for high morbidity and mortality. Appropriate diagnostic methods are essential for early detection. Microscopy examination remains the gold standard, although molecular techniques have higher sensitivity and are very useful in cases of low parasitaemia and mixed infections. The objective of this study was to evaluate a new commercial molecular diagnostic technique. METHODS: A prospective, observational, multicentre study was performed between January 2015 and April 2017. All participants were immigrants from malaria-endemic areas, who were divided into two groups: asymptomatic group and symptomatic. Samples from both groups were evaluated by a rapid diagnostic test (ImmunoQuick® Malaria + 4 RDT), microscopy examination, and two commercial molecular malaria tests (FTD Malaria and FTD Malaria Differentiation), then compared against an in-house reference PCR technique. RESULTS: In all, 250 patients were included: 164 (65.6%) in the asymptomatic group, and 86 (34.4%) in the symptomatic group. There were seven cases of asymptomatic parasitaemia (prevalence = 2.8%) that were detected only by molecular methods. In the symptomatic group, there were seven cases of submicroscopic malaria. The main species detected was Plasmodium falciparum (96.6%). The commercial molecular technique had higher sensitivity than the other methods (S = 96%) and a high rate of concordance with the in-house reference PCR technique (Kappa score = 0.93). CONCLUSIONS: The molecular techniques, although slower than microscopy, have adequate diagnostic accuracy and are very useful for the detection of P. falciparum in cases with low parasitaemia.
eng
Malaria diagnosis
PCR Plasmodium
Submicroscopic parasitaemia
Study of the diagnostic accuracy of microbiological techniques in the diagnosis of malaria in the immigrant population in Madrid
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/8749/1/StudyOfTheDiagnostic_2018.pdf
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StudyOfTheDiagnostic_2018.pdf
URL
https://repisalud.isciii.es/bitstream/20.500.12105/8749/3/StudyOfTheDiagnostic_2018.pdf.txt
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StudyOfTheDiagnostic_2018.pdf.txt