2024-03-29T08:03:34Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/83842023-10-05T09:09:00Zcom_20.500.12105_2174com_20.500.12105_2051com_20.500.12105_2173col_20.500.12105_2175
Repisalud
author
Lecarpentier, Julie
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Silvestri, Valentina
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Kuchenbaecker, Karoline B
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Barrowdale, Daniel
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Dennis, Joe
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McGuffog, Lesley
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Soucy, Penny
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Leslie, Goska
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Rizzolo, Piera
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Navazio, Anna Sara
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Valentini, Virginia
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Zelli, Veronica
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Lee, Andrew
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Amin Al Olama, Ali
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Tyrer, Jonathan P
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Southey, Melissa
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John, Esther M
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Conner, Thomas A
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Goldgar, David E
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Buys, Saundra S
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Janavicius, Ramunas
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Steele, Linda
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Ding, Yuan Chun
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Neuhausen, Susan L
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Hansen, Thomas V O
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Osorio, Ana
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Weitzel, Jeffrey N
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Toss, Angela
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Medici, Veronica
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Cortesi, Laura
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Zanna, Ines
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Palli, Domenico
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Radice, Paolo
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Manoukian, Siranoush
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Peissel, Bernard
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Azzollini, Jacopo
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Viel, Alessandra
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Cini, Giulia
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Damante, Giuseppe
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Tommasi, Stefania
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Peterlongo, Paolo
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Fostira, Florentia
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Hamann, Ute
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Evans, D Gareth
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Henderson, Alex
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Brewer, Carole
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Eccles, Diana
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Cook, Jackie
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Ong, Kai-Ren
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Walker, Lisa
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Side, Lucy E
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Porteous, Mary E
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Davidson, Rosemarie
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Hodgson, Shirley
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Frost, Debra
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Adlard, Julian
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Izatt, Louise
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Eeles, Ros
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Ellis, Steve
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Tischkowitz, Marc
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Godwin, Andrew K
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Meindl, Alfons
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Gehrig, Andrea
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Dworniczak, Bernd
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Sutter, Christian
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Engel, Christoph
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Niederacher, Dieter
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Steinemann, Doris
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Hahnen, Eric
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Hauke, Jan
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Rhiem, Kerstin
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Kast, Karin
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Arnold, Norbert
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Ditsch, Nina
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Wang-Gohrke, Shan
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Wappenschmidt, Barbara
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Wand, Dorothea
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Lasset, Christine
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Stoppa-Lyonnet, Dominique
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Belotti, Muriel
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Damiola, Francesca
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Barjhoux, Laure
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Mazoyer, Sylvie
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Van Heetvelde, Mattias
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Poppe, Bruce
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De Leeneer, Kim
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Claes, Kathleen B M
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de la Hoya, Miguel
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Garcia-Barberan, Vanesa
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Caldes, Trinidad
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Perez Segura, Pedro
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Kiiski, Johanna I
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Aittomäki, Kristiina
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Khan, Sofia
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Nevanlinna, Heli
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van Asperen, Christi J
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Vaszko, Tibor
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Kasler, Miklos
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Olah, Edith
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Balmaña, Judith
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Gutiérrez-Enríquez, Sara
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Diez, Orland
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Teulé, Alex
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Izquierdo, Angel
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Darder, Esther
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Brunet, Joan
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Del Valle, Jesús
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Feliubadalo, Lidia
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Pujana, Miquel Angel
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Lazaro, Conxi
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Arason, Adalgeir
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Agnarsson, Bjarni A
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Johannsson, Oskar Th
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Barkardottir, Rosa B
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Alducci, Elisa
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Tognazzo, Silvia
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Montagna, Marco
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Teixeira, Manuel R
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Pinto, Pedro
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Spurdle, Amanda B
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Holland, Helene
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Lee, Jong Won
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Lee, Min Hyuk
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Lee, Jihyoun
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Kim, Sung-Won
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Kang, Eunyoung
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Kim, Zisun
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Sharma, Priyanka
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Rebbeck, Timothy R
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Vijai, Joseph
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Robson, Mark
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Lincoln, Anne
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Musinsky, Jacob
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Gaddam, Pragna
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Tan, Yen Y
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Berger, Andreas
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Singer, Christian F
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Loud, Jennifer T
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Greene, Mark H
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Mulligan, Anna Marie
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Glendon, Gord
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Andrulis, Irene L
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Toland, Amanda Ewart
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Senter, Leigha
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Bojesen, Anders
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Nielsen, Henriette Roed
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Skytte, Anne-Bine
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Sunde, Lone
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Jensen, Uffe Birk
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Pedersen, Inge Sokilde
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Krogh, Lotte
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Kruse, Torben A
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Caligo, Maria A
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Yoon, Sook-Yee
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Teo, Soo-Hwang
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von Wachenfeldt, Anna
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Huo, Dezheng
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Nielsen, Sarah M
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Olopade, Olufunmilayo I
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Nathanson, Katherine L
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Domchek, Susan M
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Lorenchick, Christa
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Jankowitz, Rachel C
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Campbell, Ian
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James, Paul
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Mitchell, Gillian
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Orr, Nick
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Park, Sue Kyung
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Thomassen, Mads
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Offit, Kenneth
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Couch, Fergus J
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Simard, Jacques
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Easton, Douglas F
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Chenevix-Trench, Georgia
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Schmutzler, Rita K
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Antoniou, Antonis C
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Ottini, Laura
funder
Italian Association for Cancer Research
funder
Ministère de Économie, Innovation et Exportation (Canadá)
funder
Canadian Institutes of Health Research
funder
United States Department of Health and Human Services
funder
Cancer Research UK (Reino Unido)
funder
National Cancer Center. National R&D Program for Cancer Control (República de Corea)
funder
German Cancer Aid
funder
Fondation ARC pour la recherche sur le cancer
funder
Lietuvos Mokslo Taryba (Lituania)
funder
Asociación Española Contra el Cáncer
funder
Fundación Mutua Madrileña
funder
University of Kansas. Cancer Center (Estados Unidos)
funder
Ministerio de Economía y Competitividad (España)
funder
Finlands Akademi (Finlandia)
funder
Instituto de Salud Carlos III
funder
Dutch Research Council (Holanda)
funder
Pink Ribbons Project
funder
Biobanking and BioMolecular resources Research Infrastructure (Países Bajos)
funder
Transcan grant
funder
Government of Catalonia (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministry of Health and Welfare (Corea del Sur)
funder
Ministry of Science, Technology and Innovation (Malasia)
funder
Victorian Cancer Agency
funder
Ministry of Higher Education (Malasia)
2019-09-27T07:56:18Z
2019-09-27T07:56:18Z
2017-07-10
J Clin Oncol. 2017;35(20):2240-2250
0732-183X
http://hdl.handle.net/20.500.12105/8384
28448241
10.1200/JCO.2016.69.4935
1527-7755
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Purpose BRCA1/2 mutations increase the risk of breast and prostate cancer in men. Common genetic variants modify cancer risks for female carriers of BRCA1/2 mutations. We investigated-for the first time to our knowledge-associations of common genetic variants with breast and prostate cancer risks for male carriers of BRCA1/ 2 mutations and implications for cancer risk prediction. Materials and Methods We genotyped 1,802 male carriers of BRCA1/2 mutations from the Consortium of Investigators of Modifiers of BRCA1/2 by using the custom Illumina OncoArray. We investigated the combined effects of established breast and prostate cancer susceptibility variants on cancer risks for male carriers of BRCA1/2 mutations by constructing weighted polygenic risk scores (PRSs) using published effect estimates as weights. Results In male carriers of BRCA1/2 mutations, PRS that was based on 88 female breast cancer susceptibility variants was associated with breast cancer risk (odds ratio per standard deviation of PRS, 1.36; 95% CI, 1.19 to 1.56; P = 8.6 × 10-6). Similarly, PRS that was based on 103 prostate cancer susceptibility variants was associated with prostate cancer risk (odds ratio per SD of PRS, 1.56; 95% CI, 1.35 to 1.81; P = 3.2 × 10-9). Large differences in absolute cancer risks were observed at the extremes of the PRS distribution. For example, prostate cancer risk by age 80 years at the 5th and 95th percentiles of the PRS varies from 7% to 26% for carriers of BRCA1 mutations and from 19% to 61% for carriers of BRCA2 mutations, respectively. Conclusion PRSs may provide informative cancer risk stratification for male carriers of BRCA1/2 mutations that might enable these men and their physicians to make informed decisions on the type and timing of breast and prostate cancer risk management.
eng
Prediction of Breast and Prostate Cancer Risks in Male BRCA1 and BRCA2 Mutation Carriers Using Polygenic Risk Scores
journal article
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