2024-03-29T09:11:26Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/83512023-07-11T00:00:57Zcom_20.500.12105_2145com_20.500.12105_2051com_20.500.12105_2144col_20.500.12105_2146
Repisalud
author
Fernandez-Friera, Leticia
author
Fuster, Valentin
author
Lopez-Melgar, Beatriz
author
Oliva, Belen
author
Sanchez-Gonzalez, Javier
author
Macias, Angel
author
Perez-Asenjo, Braulio
author
Zamudio, Daniel
author
Alonso-Farto, Juan C
author
Espana, Samuel
author
Mendiguren, Jose M
author
Bueno, Hector
author
Garcia-Ruiz, Jose M
author
Ibáñez, Borja
author
Fernandez-Ortiz, Antonio
author
Sanz, Javier
funder
Centro Nacional de Investigaciones Cardiovasculares Carlos III (España)
funder
Banco Santander
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Fundación ProCNIC
2019-09-16T12:29:45Z
2019-09-16T12:29:45Z
2019-04
J Am Coll Cardiol. 2019; 73(12):1371-1382
0735-1097
http://hdl.handle.net/20.500.12105/8351
30922468
10.1016/j.jacc.2018.12.075
1558-3597
Journal of the American College of Cardiology
BACKGROUND: Atherosclerosis is a chronic inflammatory disease, but data on arterial inflammation at early stages is limited. OBJECTIVES: The purpose of this study was to characterize vascular inflammation by hybrid 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/magnetic resonance imaging (PET/MRI). METHODS: Carotid, aortic, and ilio-femoral 18F-FDG PET/MRI was performed in 755 individuals (age 40 to 54 years; 83.7% men) with known plaques detected by 2-/3-dimensional vascular ultrasound and/or coronary calcification in the PESA (Progression of Early Subclinical Atherosclerosis) study. The authors evaluated the presence, distribution, and number of arterial inflammatory foci (increased 18F-FDG uptake) and plaques with or without inflammation (coincident 18F-FDG uptake). RESULTS: Arterial inflammation was present in 48.2% of individuals (24.4% femorals, 19.3% aorta, 15.8% carotids, and 9.3% iliacs) and plaques in 90.1% (73.9% femorals, 55.8% iliacs, and 53.1% carotids). 18F-FDG arterial uptakes and plaques significantly increased with cardiovascular risk factors (p < 0.01). Coincident 18F-FDG uptakes were present in 287 of 2,605 (11%) plaques, and most uptakes were detected in plaque-free arterial segments (459 of 746; 61.5%). Plaque burden, defined by plaque presence, number, and volume, was significantly higher in individuals with arterial inflammation than in those without (p < 0.01). The number of plaques and 18F-FDG uptakes showed a positive albeit weak correlation (r = 0.25; p < 0.001). CONCLUSIONS: Arterial inflammation is highly prevalent in middle-aged individuals with known subclinical atherosclerosis. Large-scale multiterritorial PET/MRI allows characterization of atherosclerosis-related arterial inflammation and demonstrates 18F-FDG uptake in plaque-free arterial segments and, less frequently, within plaques. These findings suggest an arterial inflammatory state at early stages of atherosclerosis. (Progression of Early Subclinical Atherosclerosis [PESA]; NCT01410318).
eng
(18)F-FDG PET/MRI
Arterial inflammation
Plaque inflammation
Subclinical atherosclerosis
Vascular Inflammation in Subclinical Atherosclerosis Detected by Hybrid PET/MRI
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/8351/1/VascularInflammationSubclinicalAtherosclerosis_2019.pdf
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https://repisalud.isciii.es/bitstream/20.500.12105/8351/5/VascularInflammationSubclinicalAtherosclerosis_2019.pdf.txt
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VascularInflammationSubclinicalAtherosclerosis_2019.pdf.txt