2024-03-28T22:04:25Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/76192022-11-22T13:50:58Zcom_20.500.12105_2060com_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_2061
Repisalud
author
Martin-Odoom, Alexander
author
Brown, Charles Addoquaye
author
Odoom, John Kofi
author
Bonney, Evelyn Yayra
author
Ntim, Nana Afia Asante
author
Delgado, Elena
author
Lartey, Margaret
author
Sagoe, Kwamena William
author
Adiku, Theophilus
author
Ampofo, William Kwabena
2019-05-21T08:53:14Z
2019-05-21T08:53:14Z
2018
Virol J. 2018 Sep 17;15(1):143.
1743-422X
http://hdl.handle.net/20.500.12105/7619
30223845
10.1186/s12985-018-1051-2
1743-422X
Virology journal
BACKGROUND: Antiretrovirals have been available in Ghana since 2003 for HIV-1 positive pregnant women for prevention of mother-to-child transmission (PMTCT). Suboptimal responses to treatment observed post-PMTCT interventions necessitated the need to investigate the profile of viral mutations generated. This study investigated HIV-1 drug resistance profiles in mothers in selected centres in Ghana on treatment with a history of prophylaxis. METHODS: Genotypic Drug Resistance Testing for HIV-1 was carried out. Subtyping was done by phylogenetic analysis and Stanford HIV Database programme was used for drug resistance analysis and interpretation. To compare the significance between the different groups and the emergence of drug resistance mutations, p values were used. RESULTS: Participants who had prophylaxis before treatment, those who had treatment without prophylaxis and those yet to initiate PMTCT showed 32% (8), 5% (3) and 15% (4) HIV-1 drug resistance associated mutations respectively. The differences were significant with p value < 0.05. Resistance Associated Mutations (RAMs) were seen in 14 participants (35%) to nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs). The most common NRTI mutation found was M184 V; K103 N and A98G were the most common NNRTI mutations seen. Thymidine Analogue Mutations (TAMs) such as M41 L, K70R and T215Y were found in all the groups; the most common of the TAMs found were M41 L and T215Y. Majority of the subtypes were CRF02_AG (82%). CONCLUSION: In Ghana initiation of uninterrupted treatment upon diagnosis, coupled with drug resistance testing, would produce a better treatment outcome for HIV-1 positive pregnant women.
eng
Antiretroviral therapy
Drug resistance profiles
Phylogenetic analysis
Treatment outcome
Emergence of HIV-1 drug resistance mutations in mothers on treatment with a history of prophylaxis in Ghana
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/7619/1/EmergenceOfHIV1_2018.pdf
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https://repisalud.isciii.es/bitstream/20.500.12105/7619/3/EmergenceOfHIV1_2018.pdf.txt
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EmergenceOfHIV1_2018.pdf.txt