2024-03-29T11:43:19Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/74442023-10-06T08:06:28Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2060com_20.500.12105_2052col_20.500.12105_16979col_20.500.12105_16963col_20.500.12105_16978col_20.500.12105_2061
Repisalud
author
Vazquez-Moron, Sonia
author
Berenguer, Juan
author
González-García, Juan
author
Jimenez-Sousa, Maria Angeles
author
Canorea, Isabel
author
Guardiola, Josep M
author
Crespo, Manuel
author
Quereda, Carmen
author
Sanz, José
author
Carrero, Ana
author
Hontañón, Victor
author
Avellón, Ana
author
Resino, Salvador
funder
Red de Investigación Cooperativa en Investigación en Sida (España)
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Fundación para la Investigación y la Prevención del Sida en España
funder
Ministerio de Sanidad, Servicios Sociales e Igualdad (España)
2019-04-10T11:39:35Z
2019-04-10T11:39:35Z
2019-02-04
Sci Rep. 2019 Feb 4;9(1):1143.
2045-2322
http://hdl.handle.net/20.500.12105/7444
30718554
10.1038/s41598-018-37328-6
Scientific reports
Hepatitis E virus (HEV) has emerged as a relevant pathogen for HIV-infected patients. However, there is scarce data on HEV infection in HIV/HCV-coinfected individuals with advanced fibrosis, which seems to increase the risk of HEV infection and worsen the prognosis of liver disease. We aimed to determine the prevalence of anti-HEV antibodies, acute hepatitis E, resolved hepatitis E, and exposure to HEV in HIV/HCV-coinfected patients and to evaluate associations with clinical and epidemiological characteristics. We performed a cross-sectional study on 198 HIV/HCV-coinfected patients, 30 healthy controls and 36 HIV-monoinfected patients. We found a low concordance between techniques used for detection of anti-HEV antibodies (ELISA versus Immunoblot), particularly in HIV/HCV-coinfected patients. HIV/HCV-coinfected patients showed the highest prevalence of IgG against HEV, resolved hepatitis E, and exposure to HEV (19.2%, 17.2%, and 22.2% respectively). However, we did not find any samples positive for HEV-RNA nor significant differences between groups. Moreover, HIV/HCV-coinfected patients with CD4 T-cells <350 cells/mm3 had higher prevalence for anti-HEV IgG antibodies, resolved hepatitis E, and exposure to HEV than healthy controls or those with CD4 T-cells ≥ 350 cells/mm3 (p = 0.034, p = 0.035, and p = 0.053; respectively). In conclusion, HIV/HCV-coinfected patients in Spain have a high prevalence for IgG anti-HEV antibodies, resolved hepatitis E, and exposure to HEV; particularly patients with CD4+T-cells <350 cells/mm3.
eng
Prevalence of hepatitis E infection in HIV/HCV-coinfected patients in Spain (2012-2014)
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/7444/1/PrevalenceOfHepatitisE_2019.pdf
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https://repisalud.isciii.es/bitstream/20.500.12105/7444/5/PrevalenceOfHepatitisE_2019.pdf.txt
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PrevalenceOfHepatitisE_2019.pdf.txt