2024-03-29T11:49:29Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/71472022-11-08T11:20:10Zcom_20.500.12105_2145com_20.500.12105_2051com_20.500.12105_2144col_20.500.12105_2146
Repisalud
author
Ivanovitch, Kenzo
author
Termino, Susana
author
Torres, Miguel
funder
Ministerio de Economía y Competitividad (España)
funder
Instituto de Salud Carlos III
funder
European Molecular Biology Organization
funder
International Human Frontier Science Program Organization
2019-02-07T14:44:34Z
2019-02-07T14:44:34Z
2017
Elife. 2017; 6:e30668
2050-084X
http://hdl.handle.net/20.500.12105/7147
29202929
10.7554/eLife.30668
2050-084X
eLife
During vertebrate heart development, two progenitor populations, first and second heart fields (FHF, SHF), sequentially contribute to longitudinal subdivisions of the heart tube (HT), with the FHF contributing the left ventricle and part of the atria, and the SHF the rest of the heart. Here, we study the dynamics of cardiac differentiation and morphogenesis by tracking individual cells in live analysis of mouse embryos. We report that during an initial phase, FHF precursors differentiate rapidly to form a cardiac crescent, while limited morphogenesis takes place. In a second phase, no differentiation occurs while extensive morphogenesis, including splanchnic mesoderm sliding over the endoderm, results in HT formation. In a third phase, cardiac precursor differentiation resumes and contributes to SHF-derived regions and the dorsal closure of the HT. These results reveal tissue-level coordination between morphogenesis and differentiation during HT formation and provide a new framework to understand heart development.
eng
Cardiac crescent
Cardiac development
Developmental biology
First heart field
Heart tube
Live-imaging
Mouse
Second heart field
Stem cells
Live imaging of heart tube development in mouse reveals alternating phases of cardiac differentiation and morphogenesis
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/7147/3/LiveImagingHeartTube_2017.pdf
File
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/7147/4/LiveImagingHeartTube_2017.pdf.txt
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LiveImagingHeartTube_2017.pdf.txt