2024-03-29T15:36:12Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/69832022-09-05T12:07:26Zcom_20.500.12105_2060com_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_2061
Repisalud
author
Camacho, Maria Teresa
author
Outschoorn, I
author
Tellez, A
author
Sequí, J
funder
Instituto de Salud Carlos III
2019-01-10T11:04:36Z
2019-01-10T11:04:36Z
2005-11-10
J Autoimmune Dis. 2005 Nov 10;2:10.
17402557
http://hdl.handle.net/20.500.12105/6983
16280092
10.1186/1740-2557-2-10
1740-2557
Journal of autoimmune diseases
Recent reports have shown that some of the immunological aspects of Q fever, a rickettsiosis caused by Coxiella burnetii, could be related to self-antigen responses. The aim of this study was to determine the specificity of the autoantibody response of patients with acute and chronic Coxiella infections. Smooth muscle and cardiac muscle-specific autoantibodies were observed in significant percentages in acutely or chronically affected Q fever patients when compared to healthy volunteers. Moreover, the incidence of cardiac muscle-specific autoantibody was significantly higher among chronically ill patients compared to acutely ill patients. Moreover, a band of 50 kD of a HeLa extract was detected in most of the sera of individuals with chronic infections and previous sequence analysis suggests that this antigen presents a high degree of homology with the human actin elongation factor 1 alpha. Further research would be necessary to confirm if antibodies to human cytoskeletal proteins could be of clinical importance in chronically infected Q fever patients.
eng
Autoantibody profiles in the sera of patients with Q fever: characterization of antigens by immunofluorescence, immunoblot and sequence analysis
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/6983/1/AutoantibodyProfilesInThe_2005.pdf
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AutoantibodyProfilesInThe_2005.pdf
URL
https://repisalud.isciii.es/bitstream/20.500.12105/6983/3/AutoantibodyProfilesInThe_2005.pdf.txt
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AutoantibodyProfilesInThe_2005.pdf.txt