2024-03-28T23:58:33Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/69252022-10-10T11:36:17Zcom_20.500.12105_2053com_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_2054
Repisalud
author
Gómez-Acebo, Inés
author
Dierssen-Sotos, Trinidad
author
Palazuelos, Camilo
author
Perez-Gomez, Beatriz
author
Lope Carvajal, Virginia
author
Tusquets, Ignasi
author
Alonso, M. Henar
author
Moreno, Victor
author
Amiano, Pilar
author
Molina de la Torre, Antonio José
author
Barricarte, Aurelio
author
Tardón, Adonina
author
Camacho, Antonio
author
Peiro-Perez, Rosana
author
Marcos-Gragera, Rafael
author
Muñoz, Montse
author
Michelena-Echeveste, Maria Jesus
author
Ortega Valin, Luis
author
Guevara, Marcela
author
Castaño-Vinyals, Gemma
author
Aragones, Nuria
author
Kogevinas, Manolis
author
Pollan-Santamaria, Marina
author
Llorca, Javier
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Instituto de Salud Carlos III
funder
Junta de Castilla y León (España)
funder
Regional Government of Andalusia (España)
funder
Generalitat Valenciana (España)
funder
Fundación La Caixa
funder
Fundación Marqués de Valdecilla
funder
Government of Catalonia (España)
funder
Basque Government (España)
funder
Unión Europea. Comisión Europea
2018-12-21T10:20:22Z
2018-12-21T10:20:22Z
2016-08-10
PLoS One. 2016 Aug 10;11(8):e0159672
1932-6203
http://hdl.handle.net/20.500.12105/6925
27508297
10.1371/journal.pone.0159672
1932-6203
PloS one
INTRODUCTION: The evidence on the relationship between breast cancer and different types of antihypertensive drugs taken for at least 5 years is limited and inconsistent. Furthermore, the debate has recently been fueled again with new data reporting an increased risk of breast cancer among women with a long history of use of antihypertensive drugs compared with nonusers. METHODS: In this case-control study, we report the antihypertensive drugs-breast cancer relationship in 1,736 breast cancer cases and 1,895 healthy controls; results are reported stratifying by the women's characteristics (i.e., menopausal status or body mass index category) tumor characteristics and length of use of antihypertensive drugs. RESULTS: The relationship among breast cancer and use of calcium channel blockers (CCB) for 5 or more years had odds ratio (OR) = 1.77 (95% CI, 0.99 to 3.17). Stratifying by BMI, the OR increased significantly in the group with BMI ≥ 25 (OR 2.54, 95% CI, 1.24 to 5.22). CCBs were even more strongly associated with more aggressive tumors, (OR for invasive tumors = 1.96, 95% CI = 1.09 to 3.53; OR for non ductal cancers = 3.97, 95% CI = 1.73 to 9.05; OR for Erbb2+ cancer = 2.97, 95% CI: 1.20 to 7.32). On the other hand, premenopausal women were the only group in which angiotensin II receptor blockers may be associated with breast cancer (OR = 4.27, 95% CI = 1.32 to 13.84) but this could not be identified with any type or stage. Use of angiotensin-converting-enzyme inhibitors, beta blockers and diuretics were not associated with risk. CONCLUSIONS: In this large population-based study we found that long term use of calcium channel blockers is associated with some subtypes of breast cancer (and with breast cancer in overweight women).
eng
The Use of Antihypertensive Medication and the Risk of Breast Cancer in a Case-Control Study in a Spanish Population: The MCC-Spain Study
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/6925/1/TheUseOfAntihypertensive_2016.pdf
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https://repisalud.isciii.es/bitstream/20.500.12105/6925/5/TheUseOfAntihypertensive_2016.pdf.txt
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TheUseOfAntihypertensive_2016.pdf.txt