2024-03-28T16:48:33Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/69012023-10-06T15:58:42Zcom_20.500.12105_2060com_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_2061
Repisalud
author
Delgado, Elena
author
Cuevas, Maria Teresa
author
Dominguez, Francisco
author
Vega Rocha, Yolanda
author
Cabello, Marina
author
Fernandez-Garcia, Aurora
author
Pérez-Losada, Marcos
author
Castro, María Ángeles
author
Montero, Vanessa
author
Sánchez, Mónica
author
Mariño, Ana
author
Álvarez, Hortensia
author
Ordóñez, Patricia
author
Ocampo, Antonio
author
Miralles, Celia
author
Pérez-Castro, Sonia
author
López-Álvarez, María José
author
Rodríguez, Raúl
author
Trigo, Matilde
author
Diz-Arén, Julio
author
Hinojosa, Carmen
author
Bachiller, Pablo
author
Hernáez-Crespo, Silvia
author
Cisterna, Ramón
author
Garduño, Eugenio
author
Perez-Alvarez, Lucia
author
Thomson, Michael M
funder
Ministerio de Sanidad, Servicios Sociales e Igualdad (España)
funder
Unión Europea. Comisión Europea. 7 Programa Marco
funder
Instituto de Salud Carlos III
funder
Xunta de Galicia (España)
funder
Basque Government (España)
funder
European Network of Excellence EUROPRISE
funder
European Research Infrastructures for Poverty Related Diseases
2018-12-19T11:04:48Z
2018-12-19T11:04:48Z
2015-11-24
PLoS One. 2015 Nov 24;10(11):e0143325
1932-6203
http://hdl.handle.net/20.500.12105/6901
26599410
10.1371/journal.pone.0143325
1932-6203
PloS one
We recently reported the rapid expansion of an HIV-1 subtype F cluster among men who have sex with men (MSM) in the region of Galicia, Northwest Spain. Here we update this outbreak, analyze near full-length genomes, determine phylogenetic relationships, and estimate its origin. For this study, we used sequences of HIV-1 protease-reverse transcriptase and env V3 region, and for 17 samples, near full-length genome sequences were obtained. Phylogenetic analyses were performed via maximum likelihood. Locations and times of most recent common ancestors were estimated using Bayesian inference. Among samples analyzed by us, 100 HIV-1 F1 subsubtype infections of monophyletic origin were diagnosed in Spain, including 88 in Galicia and 12 in four other regions. Most viruses (n = 90) grouped in a subcluster (Galician subcluster), while 7 from Valladolid (Central Spain) grouped in another subcluster. At least 94 individuals were sexually-infected males and at least 71 were MSM. Seventeen near full-length genomes were uniformly of F1 subsubtype. Through similarity searches and phylogenetic analyses, we identified 18 viruses from four other Western European countries [Switzerland (n = 8), Belgium (n = 5), France (n = 3), and United Kingdom (n = 2)] and one from Brazil, from samples collected in 2005-2011, which branched within the subtype F cluster, outside of both Spanish subclusters, most of them corresponding to recently infected individuals. The most probable geographic origin and age of the Galician subcluster was Ferrol, Northwest Galicia, around 2007, while the Western European cluster probably emerged in Switzerland around 2002. In conclusion, a recently expanded HIV-1 subtype F cluster, the largest non-subtype B cluster reported in Western Europe, continues to spread among MSM in Spain; this cluster is part of a larger cluster with a wide geographic circulation in diverse Western European countries.
eng
Phylogeny and Phylogeography of a Recent HIV-1 Subtype F Outbreak among Men Who Have Sex with Men in Spain Deriving from a Cluster with a Wide Geographic Circulation in Western Europe
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/6901/1/PhylogenyandPhylogeographyof_2015.pdf
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https://repisalud.isciii.es/bitstream/20.500.12105/6901/3/PhylogenyandPhylogeographyof_2015.pdf.txt
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PhylogenyandPhylogeographyof_2015.pdf.txt