2024-03-29T09:50:09Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/68892022-12-01T18:39:13Zcom_20.500.12105_2060com_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_2061
Repisalud
author
Scorzoni, Liliana
author
de Lucas, Maria Pilar
author
Mesa-Arango, Ana Cecilia
author
Fusco-Almeida, Ana Marisa
author
Lozano, Encarnacion
author
Cuenca-Estrella, Manuel
author
Mendes-Giannini, Maria Jose
author
Zaragoza, Oscar
2018-12-18T15:00:35Z
2018-12-18T15:00:35Z
2013-03-28
PLoS One. 2013;8(3):e60047
1932-6203
http://hdl.handle.net/20.500.12105/6889
23555877
10.1371/journal.pone.0060047
1932-6203
PloS one
The incidence of opportunistic fungal infections has increased in recent decades due to the growing proportion of immunocompromised patients in our society. Candida krusei has been described as a causative agent of disseminated fungal infections in susceptible patients. Although its prevalence remains low among yeast infections (2-5%), its intrinsic resistance to fluconazole makes this yeast important from epidemiologic aspects. Non mammalian organisms are feasible models to study fungal virulence and drug efficacy. In this work we have used the lepidopteran Galleria mellonella and the nematode Caenorhabditis elegans as models to assess antifungal efficacy during infection by C. krusei. This yeast killed G. mellonella at 25, 30 and 37°C and reduced haemocytic density. Infected larvae melanized in a dose-dependent manner. Fluconazole did not protect against C. krusei infection, in contrast to amphotericin B, voriconazole or caspofungin. However, the doses of these antifungals required to obtain larvae protection were always higher during C. krusei infection than during C. albicans infection. Similar results were found in the model host C. elegans. Our work demonstrates that non mammalian models are useful tools to investigate in vivo antifungal efficacy and virulence of C. krusei.
eng
Antifungal efficacy during Candida krusei infection in non-conventional models correlates with the yeast in vitro susceptibility profile
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/6889/1/AntifungalEfficacyDuringCandida_2013.pdf
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AntifungalEfficacyDuringCandida_2013.pdf
URL
https://repisalud.isciii.es/bitstream/20.500.12105/6889/3/AntifungalEfficacyDuringCandida_2013.pdf.txt
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AntifungalEfficacyDuringCandida_2013.pdf.txt