2024-03-28T15:00:23Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/68292023-01-26T13:51:40Zcom_20.500.12105_2109com_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_2110
Repisalud
author
Fernandez, Eva M
author
Díaz-Ceso, María D
author
Vilar, Marçal
funder
Ministerio de Economía y Competitividad (España)
2018-12-12T15:08:44Z
2018-12-12T15:08:44Z
2015-01-22
PLoS One. 2015 Jan 22;10(1):e0117206
1932-6203
http://hdl.handle.net/20.500.12105/6829
25612294
10.1371/journal.pone.0117206
1932-6203
PloS one
Intrinsically disordered proteins (IDPs) are abundant in complex organisms. Due to their promiscuous nature and their ability to adopt several conformations IDPs constitute important points of network regulation. The family of Brain Expressed and X-linked (Bex) proteins consists of 5 members in humans (Bex1-5). Recent reports have implicated Bex proteins in transcriptional regulation and signaling pathways involved in neurodegeneration, cancer, cell cycle and tumor growth. However, structural and biophysical data for this protein family is almost non-existent. We used bioinformatics analyses to show that Bex proteins contain long regions of intrinsic disorder which are conserved across all members. Moreover, we confirmed the intrinsic disorder by circular dichroism spectroscopy of Bex1 after expression and purification in E. coli. These observations strongly suggest that Bex proteins constitute a new group of IDPs. Based on these findings, together with the demonstrated promiscuity of Bex proteins and their involvement in different signaling pathways, we propose that Bex family members play important roles in the formation of protein network hubs.
eng
Brain expressed and X-linked (Bex) proteins are intrinsically disordered proteins (IDPs) and form new signaling hubs
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/6829/1/BrainExpressedandX-Linked_2015.pdf
File
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BrainExpressedandX-Linked_2015.pdf
URL
https://repisalud.isciii.es/bitstream/20.500.12105/6829/3/BrainExpressedandX-Linked_2015.pdf.txt
File
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BrainExpressedandX-Linked_2015.pdf.txt