2024-03-28T11:33:15Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/65162022-06-08T08:23:48Zcom_20.500.12105_2145com_20.500.12105_2051com_20.500.12105_2144col_20.500.12105_2146
Repisalud
author
Halcox, Julian P. J.
author
Roy, Carine
author
Tubach, Florence
author
Banegas, José Ramón
author
Dallongeville, Jean
author
De Backer, Guy
author
Guallar, Eliseo
author
Sazova, Oguen
author
Medina, Jesus
author
Perk, Joep
author
Steg, Philippe Gabriel
author
Rodríguez-Artalejo, Fernando
author
Borghi, Claudio
funder
Oxford PharmaGenesis
2018-10-25T08:19:45Z
2018-10-25T08:19:45Z
2014
BMC Cardiovasc Disord. 2014; 14(1):25
1471-2261
http://hdl.handle.net/20.500.12105/6516
24564178
10.1186/1471-2261-14-25
BMC Cardiovascular Disorders
Background: Elevated C-reactive protein (CRP) levels are associated with high cardiovascular risk, and might identify patients who could benefit from more carefully adapted risk factor management. We have assessed the prevalence of elevated CRP levels in patients with one or more traditional cardiovascular risk factors. Methods: Data were analysed from the European Study on Cardiovascular Risk Prevention and Management in Usual Daily Practice (EURIKA, ClinicalTrials. gov Identifier: NCT00882336), which included patients (aged = 50 years) from 12 European countries with at least one traditional cardiovascular risk factor but no history of cardiovascular disease. Analysis was also carried out on the subset of patients without diabetes mellitus who were not receiving statin therapy. Results: In the overall population, CRP levels were positively correlated with body mass index and glycated haemoglobin levels, and were negatively correlated with high- density lipoprotein cholesterol levels. CRP levels were also higher in women, those at higher traditionally estimated cardiovascular risk and those with greater numbers of metabolic syndrome markers. Among patients without diabetes mellitus who were not receiving statin therapy, approximately 30\% had CRP levels >= 3 mg/ L, and approximately 50\% had CRP levels = 2 mg/ L, including those at intermediate levels of traditionally estimated cardiovascular risk. Conclusions: CRP levels are elevated in a large proportion of patients with at least one cardiovascular risk factor, without diabetes mellitus who are not receiving statin therapy, suggesting a higher level of cardiovascular risk than predicted according to conventional risk estimation systems.
eng
C-reactive protein
Cardiovascular disease
Epidemiology
Risk factors/global assessment
CORONARY-HEART-DISEASE
PRIMARY PREVENTION
CLINICAL-PRACTICE
HEALTHY-ADULTS
PREDICTION
WOMEN
INFLAMMATION
POPULATION
MORTALITY
JUPITER
C-reactive protein levels in patients at cardiovascular risk: EURIKA study
journal article
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