2024-03-19T01:08:58Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/65112023-10-11T08:49:35Zcom_20.500.12105_2174com_20.500.12105_2051com_20.500.12105_2173col_20.500.12105_2175
Repisalud
author
Klein, Alison P
author
Wolpin, Brian M
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Risch, Harvey A
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Stolzenberg-Solomon, Rachael Z
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Mocci, Evelina
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Zhang, Mingfeng
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Canzian, Federico
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Childs, Erica J
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Hoskins, Jason W
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Jermusyk, Ashley
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Zhong, Jun
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Wentzensen, Nicolas
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Albanes, Demetrius
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White, Emily
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Yu, Herbert
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Yu, Kai
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Zheng, Wei
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Kraft, Peter
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Li, Donghui
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Obazee, Ofure
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Petersen, Gloria M
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Brais, Lauren
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Amundadottir, Laufey T
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Andreotti, Gabriella
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Arslan, Alan A
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Buring, Julie
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Babic, Ana
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Bamlet, William R
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Beane-Freeman, Laura
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Chaffee, Kari G
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Berndt, Sonja I
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Blackford, Amanda
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Chung, Charles C
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Borges, Michael
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Borgida, Ayelet
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Bracci, Paige M
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Brennan, Paul
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Brenner, Hermann
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Bueno-de-Mesquita, Bas
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Campa, Daniele
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Capurso, Gabriele
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Cavestro, Giulia Martina
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Cleary, Sean
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Cotterchio, Michelle
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Goodman, Gary E
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Dijk, Frederike
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Duell, Eric J
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Foretova, Lenka
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Hartge, Patricia
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Fuchs, Charles
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Funel, Niccola
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Gallinger, Steven
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Herman, Joseph
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M Gaziano, J Michael
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Gazouli, Maria
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Holcatova, Ivana
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Giles, Graham G
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Giovannucci, Edward
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Goggins, Michael
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Goodman, Phyllis J
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Hackert, Thilo
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Haiman, Christopher
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Hasan, Manal
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Hegyi, Peter
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Helzlsouer, Kathy J
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Holly, Elizabeth A
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Hoover, Robert
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Kurtz, Robert J
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Hung, Rayjean J
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Jacobs, Eric J
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Jamroziak, Krzysztof
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Lee, I-Min
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Janout, Vladimir
author
Kaaks, Rudolf
author
Khaw, Kay-Tee
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Mambrini, Andrea
author
Klein, Eric A
author
Kogevinas, Manolis
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Mannisto, Satu
author
Kooperberg, Charles
author
Kulke, Matthew H
author
Kupcinskas, Juozas
author
Laheru, Daniel
author
Landi, Stefano
author
Lawlor, Rita T
author
LeMarchand, Loic
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Lu, Lingeng
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Malats, Núria
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Milne, Roger L
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Mohelníková-Duchoňová, Beatrice
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Rothman, Nathaniel
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Neale, Rachel E
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Neoptolemos, John P
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Oberg, Ann L
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Shu, Xiao-Ou
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Olson, Sara H
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Orlow, Irene
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Pasquali, Claudio
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Sund, Malin
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Patel, Alpa V
author
Peters, Ulrike
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Talar-Wojnarowska, Renata
author
Pezzilli, Raffaele
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Porta, Miquel
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Real Arribas, Francisco
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Scelo, Ghislaine
author
Sesso, Howard D
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Severi, Gianluca
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Silverman, Debra
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Smith, Jill P
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Soucek, Pavel
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Tavano, Francesca
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Thornquist, Mark D
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Zeleniuch-Jacquotte, Anne
author
Tobias, Geoffrey S
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Van Den Eeden, Stephen K
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Vashist, Yogesh
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Chanock, Stephen
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Visvanathan, Kala
author
Vodicka, Pavel
author
Wactawski-Wende, Jean
author
Chen, Fei
author
Wang, Zhaoming
funder
Lung Cancer Research Foundation
funder
Sol Goldman Pancreas Cancer Research Center
funder
Geoffrey Beene Foundation
funder
Arnold and Arlene Goldstein Family Foundation
funder
National Health and Medical Research Council (Australia)
funder
Czech Science Foundation
funder
Joan Rombauer Pancreatic Cancer Foundation
funder
NIH - National Cancer Institute (NCI) (Estados Unidos)
funder
Instituto de Salud Carlos III
funder
Ministerio de Ciencia y Tecnología (España)
funder
Red Temática de Investigación Cooperativa en Cáncer (RTICC) (España)
funder
Centro de Investigación Biomédica en Red - CIBERESP (Epidemiología y Salud Pública)
2018-10-25T07:55:15Z
2018-10-25T07:55:15Z
2018-02-08
Nat Commun. 2018; 9(1): 556.
2041-1723
http://hdl.handle.net/20.500.12105/6511
29422604
10.1038/s41467-018-02942-5
2041-1723
Nature communications
In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 × 10-8). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 × 10-14), rs2941471 at 8q21.11 (HNF4G, P = 6.60 × 10-10), rs4795218 at 17q12 (HNF1B, P = 1.32 × 10-8), and rs1517037 at 18q21.32 (GRP, P = 3.28 × 10-8). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic data sets provides molecular support of NOC2L as a pancreatic cancer susceptibility gene.
eng
BODY-MASS INDEX
ASSOCIATION ANALYSES
GENE-EXPRESSION
TRANSCRIPTION FACTORS
RISK
IMPUTATION
DISEASE
ADENOCARCINOMA
Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer
journal article
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