2024-03-28T13:59:30Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/53972023-09-28T08:43:36Zcom_20.500.12105_2145com_20.500.12105_2051com_20.500.12105_2144col_20.500.12105_2146
Repisalud
author
Saravia, Gabriela
author
Civeira, Fernando
author
Hurtado-Roca, Yamilee
author
Andrés, Eva
author
Leon, Montserrat
author
Pocovi, Miguel
author
Ordovas, Jose M
author
Guallar, Eliseo
author
Fernandez-Ortiz, Antonio
author
Casasnovas, Jose Antonio
author
Laclaustra, Martin
funder
Instituto de Salud Carlos III
funder
Gobierno de Perú
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2017-11-27T13:49:51Z
2017-11-27T13:49:51Z
2015
PLoS One. 2015; 10(8):e0132244
1932-6203
http://hdl.handle.net/20.500.12105/5397
26241903
10.1371/journal.pone.0132244
PLoS One
Background and Aims
Glycated hemoglobin (HbA1c) is currently used to diagnose diabetes
mellitus, while insulin has been relegated to research. Both, however,
may help understanding the metabolic syndrome and profiling patients. We
examined the association of HbA1c and fasting insulin with clustering of
metabolic syndrome criteria and insulin resistance as two essential
characteristics of the metabolic syndrome.
Methods
We used baseline data from 3200 non-diabetic male participants in the
Aragon Workers' Health Study. We conducted analysis to estimate
age-adjusted odds ratios (ORs) across tertiles of HbA1c and insulin.
Fasting glucose and Homeostatic model assessment - Insulin Resistance
were used as reference. Here we report the uppermost-to-lowest tertile
ORs (95\% CI).
Results
Mean age (SD) was 48.5 (8.8) years and 23\% of participants had
metabolic syndrome. The ORs for metabolic syndrome criteria tended to be
higher across HbA1c than across glucose, except for high blood pressure.
Insulin was associated with the criteria more strongly than HbA1c and
similarly to Homeostatic model assessment - Insulin Resistance
(HOMA-IR). For metabolic syndrome, the OR of HbA1c was 2.68, of insulin,
11.36, of glucose, 7.03, and of HOMA-IR, 14.40. For the clustering of 2
or more non-glycemic criteria, the OR of HbA1c was 2.10, of insulin,
8.94, of glucose, 1.73, and of HOMA-IR, 7.83. All ORs were statistically
significant. The areas under the receiver operating characteristics
curves for metabolic syndrome were 0.670 (across HbA1c values) and 0.770
(across insulin values), and, for insulin resistance, 0.647 (HbA1c) and
0.995 (insulin). Among non-metabolic syndrome patients, a small insulin
elevation identified risk factor clustering.
Conclusions
HbA1c and specially insulin levels were associated with metabolic
syndrome criteria, their clustering, and insulin resistance. Insulin
could provide early information in subjects prone to develop metabolic
syndrome.
eng
CARDIOVASCULAR RISK
DIABETES-MELLITUS
RESISTANCE
ADULTS
HYPERINSULINEMIA
ASSOCIATION
DISEASE
GLUCOSE
A1C
SENSITIVITY
Glycated Hemoglobin, Fasting Insulin and the Metabolic Syndrome in
Males. Cross-Sectional Analyses of the Aragon Workers' Health Study
Baseline
journal article
URL
https://repisalud.isciii.es/bitstream/20.500.12105/5397/1/GlycatedHemoglobinFastingInsulin_2015.pdf
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GlycatedHemoglobinFastingInsulin_2015.pdf
URL
https://repisalud.isciii.es/bitstream/20.500.12105/5397/2/GlycatedHemoglobinFastingInsulin_2015_suppl.docx
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GlycatedHemoglobinFastingInsulin_2015_suppl.docx
URL
https://repisalud.isciii.es/bitstream/20.500.12105/5397/7/GlycatedHemoglobinFastingInsulin_2015.pdf.txt
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GlycatedHemoglobinFastingInsulin_2015.pdf.txt