2024-03-29T10:05:17Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/51672023-10-06T07:43:29Zcom_20.500.12105_2152com_20.500.12105_2051com_20.500.12105_2144col_20.500.12105_2153
Repisalud
author
Velasco, Carlos
author
Mateo, Jesus
author
Santos, Arnoldo
author
Mota-Cobian, Adriana
author
Herranz, Fernando
author
Pellico, Juan
author
Mota, Ruben A.
author
Espana, Samuel
author
Ruiz-Cabello, Jesus
funder
Ministerio de Economía y Competitividad (España)
funder
Instituto de Salud Carlos III
funder
Ministerio de Educación, Cultura y Deporte (España)
funder
Comunidad de Madrid (España)
funder
Fundación ProCNIC
2017-10-20T10:33:50Z
2017-10-20T10:33:50Z
2017
EJNMMI Res. 2017; 7(1):7
2191-219X
http://hdl.handle.net/20.500.12105/5167
28101850
10.1186/s13550-017-0259-2
EJNMMI Research
Background: In vivo determination of regional pulmonary blood flow (PBF) is a valuable tool for the evaluation of many lung diseases. In this study, the use of Ga-68-DOTA PET for the in vivo quantitative determination of regional PBF is proposed. This methodology was implemented and tested in healthy pigs and validated using fluorescent microspheres. The study was performed on young large white pigs (n = 4). To assess the reproducibility and consistency of the method, three PET scans were obtained for each animal. Each radiotracer injection was performed simultaneously to the injection of fluorescent microspheres. PBF images were generated applying a two-compartment exchange model over the dynamic PET images. PET and microspheres values were compared by regression analysis and Bland-Altman plot. Results: The capability of the proposed technique to produce 3D regional PBF images was demonstrated. The correlation evaluation between Ga-68-DOTA PET and microspheres showed a good and significant correlation (r = 0.74, P < 0.001). Conclusions: Assessment of PBF with the proposed technique allows combining the high quantitative accuracy of PET imaging with the use of Ga-68/Ge-68 generators. Thus, Ga-68-DOTA PET emerges as a potential inexpensive method for measuring PBF in clinical settings with an extended use.
eng
PET
Pulmonary blood flow
Gallium-68
Fluorescent microspheres
POSITRON-EMISSION-TOMOGRAPHY
MYOCARDIAL-PERFUSION
LUNG PERFUSION
PIG MODEL
QUANTIFICATION
MICROSPHERES
VALIDATION
CT
DEPOSITION
VOLUME
Assessment of regional pulmonary blood flow using Ga-68-DOTA PET
journal article
URL
https://repisalud.isciii.es/bitstream/20.500.12105/5167/1/AssessmentOfRegionalPulmonaryBlood_2017
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MD5
1e318c86994dbd04ea1b6b176ae86ca7
2003677
application/pdf
AssessmentOfRegionalPulmonaryBlood_2017
URL
https://repisalud.isciii.es/bitstream/20.500.12105/5167/18/AssessmentOfRegionalPulmonaryBlood_2017.txt
File
MD5
9e7770f163994294b6545b80cc2a1bb0
40695
text/plain
AssessmentOfRegionalPulmonaryBlood_2017.txt