2024-03-28T22:31:31Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/48402022-09-05T12:05:40Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2060com_20.500.12105_2052col_20.500.12105_16978col_20.500.12105_2061
Repisalud
author
Guzman-Fulgencio, Maria
author
Berenguer, Juan
author
Jimenez-Sousa, Maria Angeles
author
Pineda-Tenor, Daniel
author
Aldámiz-Echevarria, Teresa
author
Trento, Alfonsina
author
Carrero, Ana
author
Garcia-Alvarez, Monica
author
Tejerina, Francisco
author
Diez, Cristina
author
Vazquez-Moron, Sonia
author
Resino, Salvador
funder
Fundación para la Investigación y la Prevención del Sida en España
funder
Instituto de Salud Carlos III
funder
European Regional Development Fund
2017-09-04T16:32:51Z
2017-09-04T16:32:51Z
2015-06-30
J Transl Med. 2015;13:206
http://hdl.handle.net/20.500.12105/4840
26123260
10.1186/s12967-015-0577-y
1479-5876
Journal of Translational Medicine
Background
Interleukin-7 (IL-7) is a critical factor for T cell development and for maintaining and restoring homeostasis of mature T cells. Polymorphisms at α-chain of the IL-7 receptor (IL7R or CD127) gene are related to evolution of HIV-infection, but there are no data concerning the evolution of hepatitis C virus (HCV) infection. The aim of this study was to analyze the association between IL7R polymorphisms and severe liver disease in HCV/HIV coinfected patients.
Methods
We performed a cross-sectional study in 220 naïve patients who underwent a liver biopsy. IL7R polymorphisms (rs6897932, rs987106 and rs3194051) were genotyped using the GoldenGate® assay. The outcome variables were: (a) liver biopsy: advanced fibrosis (F ≥ 3), severe activity grade (A3); (b) non-invasive indexes: advanced fibrosis (APRI ≥1.5 and FIB-4 ≥3.25). Logistic regression analysis was used to investigate the association between IL7R polymorphisms and outcome variables. This test gives the differences between groups and the odds ratio (OR) for liver disease.
Results
Patients with rs6897932 CC genotype had higher likelihood of having A3 than patients with rs6897932 CT/TT (adjusted odds ratio (aOR) = 4.16; p = 0.026). Patients with rs987106 TT genotype had higher odds of having F ≥ 3 (aOR = 3.09; p = 0.009) than rs987106 AA/AT carriers. Finally, patients with rs3194051 AA genotype had higher odds of having severe liver fibrosis (F ≥ 3; APRI ≥1.5, and FIB4 ≥3.25) than patients with rs3194051 AG/GG genotype [aOR = 2.73 (p = 0.010); aOR = 2.52 (p = 0.029); and aOR = 4.01 (p = 0.027); respectively]. The CTA haplotype (comprised of rs6897932, rs987106, and rs3194051) carriers had higher odds of having F ≥ 3 (aOR = 1.85; p = 0.012), APRI ≥1.5 (aOR = 1.94; p = 0.023), and FIB4 ≥3.25 (aOR = 2.47; p = 0.024). Conversely, the CAG haplotype carriers had lower odds of having F ≥ 3 (aOR = 0.48; p = 0.011), APRI ≥1.5 (aOR = 0.48; p = 0.029), and FIB4 ≥3.25 (aOR = 0.29; p = 0.010).
Conclusions
The presence of IL7R polymorphisms seems to be related to severe liver disease in HIV/HCV coinfected patients, because patients with unfavorable IL7R genotypes (rs6897932 CC, rs987106 TT, and rs3194051AA) had a worse prognosis of CHC.
eng
HIV/AIDS
Hepatic fibrosis
Chronic hepatitis C
IL7R
SNPs
Association between IL7R polymorphisms and severe liver disease in HIV/HCV coinfected patients: a cross-sectional study
journal article
URL
https://repisalud.isciii.es/bitstream/20.500.12105/4840/1/AssociationBetweenIL7RPolymorphisms_2015.pdf
File
MD5
80989976d3e2829a13f6c65539ac31b3
1042879
application/pdf
AssociationBetweenIL7RPolymorphisms_2015.pdf
URL
https://repisalud.isciii.es/bitstream/20.500.12105/4840/20/12967_2015_Article_577.pdf.txt
File
MD5
8e8526406170a1ab49b8c51d39df6407
45665
text/plain
12967_2015_Article_577.pdf.txt
URL
https://repisalud.isciii.es/bitstream/20.500.12105/4840/22/AssociationBetweenIL7RPolymorphisms_2015.pdf.txt
File
MD5
8e8526406170a1ab49b8c51d39df6407
45665
text/plain
AssociationBetweenIL7RPolymorphisms_2015.pdf.txt
URL
https://repisalud.isciii.es/bitstream/20.500.12105/4840/26/AssociationBetweenIL7RPolymorphisms_2015.pdf.txt
File
MD5
8e8526406170a1ab49b8c51d39df6407
45665
text/plain
AssociationBetweenIL7RPolymorphisms_2015.pdf.txt