2024-03-28T20:51:00Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/156702023-03-18T02:00:48Zcom_20.500.12105_2145com_20.500.12105_2051com_20.500.12105_2144col_20.500.12105_2146
Repisalud
author
Dosil, Sara G
author
Lopez-Cobo, Sheila
author
Rodriguez-Galan, Ana
author
Fernandez-Delgado, Irene
author
Ramirez-Huesca, Marta
author
Milan-Rois, Paula
author
Castellanos, Milagros
author
Somoza, Alvaro
author
Gómez, Manuel José
author
Reyburn, Hugh T
author
Vales-Gomez, Mar
author
Sánchez Madrid, Francisco
author
Fernandez-Messina, Lola
funder
Fundación BBVA
funder
Comunidad de Madrid (España)
funder
Ministerio de Economía y Competitividad (España)
funder
Instituto de Salud Carlos III
funder
Fundación Ramón Areces
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2023-03-17T12:25:58Z
2023-03-17T12:25:58Z
2022-07-29
Elife. 2022 Jul 29;11:e76319
http://hdl.handle.net/20.500.12105/15670
35904241
10.7554/eLife.76319
2050-084X
eLife
Natural killer (NK) cells recognize and kill target cells undergoing different types of stress. NK cells are also capable of modulating immune responses. In particular, they regulate T cell functions. Small RNA next-generation sequencing of resting and activated human NK cells and their secreted extracellular vesicles (EVs) led to the identification of a specific repertoire of NK-EV-associated microRNAs and their post-transcriptional modifications signature. Several microRNAs of NK-EVs, namely miR-10b-5p, miR-92a-3p, and miR-155-5p, specifically target molecules involved in Th1 responses. NK-EVs promote the downregulation of GATA3 mRNA in CD4+ T cells and subsequent TBX21 de-repression that leads to Th1 polarization and IFN-γ and IL-2 production. NK-EVs also have an effect on monocyte and moDCs (monocyte-derived dendritic cells) function, driving their activation and increased presentation and costimulatory functions. Nanoparticle-delivered NK-EV microRNAs partially recapitulate NK-EV effects in mice. Our results provide new insights on the immunomodulatory roles of NK-EVs that may help to improve their use as immunotherapeutic tools.
eng
Natural killer (NK) cell-derived extracellular-vesicle shuttled microRNAs control T cell responses.
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/15670/1/Natural%20killer%20%28NK%29%20cell_derived%20Elife%202022.pdf
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Natural killer (NK) cell_derived Elife 2022.pdf
URL
https://repisalud.isciii.es/bitstream/20.500.12105/15670/4/Natural%20killer%20%28NK%29%20cell_derived%20Elife%202022.pdf.txt
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Natural killer (NK) cell_derived Elife 2022.pdf.txt