2024-03-29T09:59:02Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/150602023-11-02T17:47:39Zcom_20.500.12105_2067com_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_2068
Repisalud
author
Gilles, Liese
author
Govarts, Eva
author
Rodriguez Martin, Laura
author
Andersson, Anna-Maria
author
Appenzeller, Brice M R
author
Barbone, Fabio
author
Castaño, Argelia
author
Coertjens, Dries
author
Den Hond, Elly
author
Dzhedzheia, Vazha
author
Eržen, Ivan
author
Esteban-Lopez, Marta
author
Fábelová, Lucia
author
Fillol, Clémence
author
Franken, Carmen
author
Frederiksen, Hanne
author
Gabriel, Catherine
author
Haug, Line Småstuen
author
Horvat, Milena
author
Halldórsson, Thórhallur Ingi
author
Janasik, Beata
author
Holcer, Nataša Janev
author
Kakucs, Réka
author
Karakitsios, Spyros
author
Katsonouri, Andromachi
author
Klánová, Jana
author
Kold-Jensen, Tina
author
Kolossa-Gehring, Marike
author
Konstantinou, Corina
author
Koponen, Jani
author
Lignell, Sanna
author
Lindroos, Anna Karin
author
Makris, Konstantinos C
author
Mazej, Darja
author
Morrens, Bert
author
Palkovicova Murinova, Lubica
author
Namorado, Sónia
author
Pedraza-Diaz, Susana
author
Peisker, Jasmin
author
Probst-Hensch, Nicole
author
Rambaud, Loïc
author
Rosolen, Valentina
author
Rucic, Enrico
author
Rüther, Maria
author
Sarigiannis, Dimosthenis
author
Tratnik, Janja Snoj
author
Standaert, Arnout
author
Stewart, Lorraine
author
Szigeti, Tamás
author
Thomsen, Cathrine
author
Tolonen, Hanna
author
Eiríksdóttir, Ása
author
Van Nieuwenhuyse, An
author
Verheyen, Veerle J
author
Vlaanderen, Jelle
author
Vogel, Nina
author
Wasowicz, Wojciech
author
Weber, Till
author
Zock, Jan-Paul
author
Sepai, Ovnair
author
Schoeters, Greet
funder
Unión Europea. Comisión Europea. H2020
2022-10-18T10:38:02Z
2022-10-18T10:38:02Z
2022-06-01
Int J Environ Res Public Health. 2022 Jun 1;19(11):6787.
http://hdl.handle.net/20.500.12105/15060
35682369
10.3390/ijerph19116787
1660-4601
International Journal of Environmental Research and Public Health
Human biomonitoring has become a pivotal tool for supporting chemicals' policies. It provides information on real-life human exposures and is increasingly used to prioritize chemicals of health concern and to evaluate the success of chemical policies. Europe has launched the ambitious REACH program in 2007 to improve the protection of human health and the environment. In October 2020 the EU commission published its new chemicals strategy for sustainability towards a toxic-free environment. The European Parliament called upon the commission to collect human biomonitoring data to support chemical's risk assessment and risk management. This manuscript describes the organization of the first HBM4EU-aligned studies that obtain comparable human biomonitoring (HBM) data of European citizens to monitor their internal exposure to environmental chemicals. The HBM4EU-aligned studies build on existing HBM capacity in Europe by aligning national or regional HBM studies. The HBM4EU-aligned studies focus on three age groups: children, teenagers, and adults. The participants are recruited between 2014 and 2021 in 11 to 12 primary sampling units that are geographically distributed across Europe. Urine samples are collected in all age groups, and blood samples are collected in children and teenagers. Auxiliary information on socio-demographics, lifestyle, health status, environment, and diet is collected using questionnaires. In total, biological samples from 3137 children aged 6-12 years are collected for the analysis of biomarkers for phthalates, HEXAMOLL® DINCH, and flame retardants. Samples from 2950 teenagers aged 12-18 years are collected for the analysis of biomarkers for phthalates, Hexamoll® DINCH, and per- and polyfluoroalkyl substances (PFASs), and samples from 3522 adults aged 20-39 years are collected for the analysis of cadmium, bisphenols, and metabolites of polyaromatic hydrocarbons (PAHs). The children's group consists of 50.4% boys and 49.5% girls, of which 44.1% live in cities, 29.0% live in towns/suburbs, and 26.8% live in rural areas. The teenagers' group includes 50.6% girls and 49.4% boys, with 37.7% of residents in cities, 31.2% in towns/suburbs, and 30.2% in rural areas. The adult group consists of 52.6% women and 47.4% men, 71.9% live in cities, 14.2% in towns/suburbs, and only 13.4% live in rural areas. The study population approaches the characteristics of the general European population based on age-matched EUROSTAT EU-28, 2017 data; however, individuals who obtained no to lower educational level (ISCED 0-2) are underrepresented. The data on internal human exposure to priority chemicals from this unique cohort will provide a baseline for Europe's strategy towards a non-toxic environment and challenges and recommendations to improve the sampling frame for future EU-wide HBM surveys are discussed.
eng
Adults
Children
Human Biomonitoring
Teenagers
Joint HBM4EU survey
Harmonization of Human Biomonitoring Studies in Europe: Characteristics of the HBM4EU-Aligned Studies Participants
journal article
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
URL
https://repisalud.isciii.es/bitstream/20.500.12105/15060/1/HarmonizationOfHumanBiomonitoring_2022.pdf
File
MD5
ae63857dc487a5c3a43a4b21de766a94
1190970
application/pdf
HarmonizationOfHumanBiomonitoring_2022.pdf
URL
https://repisalud.isciii.es/bitstream/20.500.12105/15060/2/HarmonizationOfHumanBiomonitoringSupplementary_2022.pdf
File
MD5
9447101703203c96ef62f2a1b69710df
640828
application/pdf
HarmonizationOfHumanBiomonitoringSupplementary_2022.pdf
URL
https://repisalud.isciii.es/bitstream/20.500.12105/15060/5/HarmonizationOfHumanBiomonitoring_2022.pdf.txt
File
MD5
8719fcf56cf3a5b63bb035b43a14cf75
86961
text/plain
HarmonizationOfHumanBiomonitoring_2022.pdf.txt
URL
https://repisalud.isciii.es/bitstream/20.500.12105/15060/7/HarmonizationOfHumanBiomonitoringSupplementary_2022.pdf.txt
File
MD5
b52e7b83e8eb4ebfd3f3d59cb18d4e2a
79241
text/plain
HarmonizationOfHumanBiomonitoringSupplementary_2022.pdf.txt