2024-03-28T11:55:00Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/143902023-10-10T10:12:40Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2053com_20.500.12105_2052col_20.500.12105_16978col_20.500.12105_16963col_20.500.12105_16962col_20.500.12105_16958col_20.500.12105_2054
Repisalud
author
Salto-Alejandre, Sonsoles
author
Palacios-Baena, Zaira R
author
Arribas, José Ramón
author
Berenguer, Juan
author
Carratalà, Jordi
author
Jarrin-Vera, Inmaculada
author
Ryan, Pablo
author
Miguel-Montero, Marta de
author
Rodríguez-Baño, Jesús
author
Pachón, Jerónimo
author
COVID-19@Spain Study Group
funder
Instituto de Salud Carlos III
funder
Fundación Seimc-Gesida
funder
Plan Nacional de I+D+i (España)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Red de Investigación Cooperativa en Investigación en Sida (España)
funder
RETICS-Investigación en Patología Infecciosa (REIPI-ISCIII) (España)
funder
Ministerio de Ciencia e Innovación (España)
funder
Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas)
2022-05-11T12:24:04Z
2022-05-11T12:24:04Z
2022-02
Biomed Pharmacother. 2022 Feb;146:112572.
http://hdl.handle.net/20.500.12105/14390
34954640
10.1016/j.biopha.2021.112572
1950-6007
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
Background: Interferon-β is an attractive drug for repurposing and use in the treatment of COVID-19, based on its in vitro antiviral activity and the encouraging results from clinical trials. The aim of this study was to analyze the impact of early interferon-β treatment in patients admitted with COVID-19 during the first wave of the pandemic. Methods: This post hoc analysis of a COVID-19@Spain multicenter cohort included 3808 consecutive adult patients hospitalized with COVID-19 from 1 January to 17 March 2020. The primary endpoint was 30-day all-cause mortality, and the main exposure of interest was subcutaneous administration of interferon-β, defined as early if started ≤ 3 days from admission. Multivariate logistic and Cox regression analyses were conducted to identify the associations of different variables with receiving early interferon-β therapy and to assess its impact on 30-day mortality. A propensity score was calculated and used to both control for confounders and perform a matched cohort analysis. Results: Overall, 683 patients (17.9%) received early interferon-β therapy. These patients were more severely ill. Adjusted HR for mortality with early interferon-β was 1.03 (95% CI, 0.82-1.30) in the overall cohort, 0.96 (0.82-1.13) in the PS-matched subcohort, and 0.89 (0.60-1.32) when interferon-β treatment was analyzed as a time-dependent variable. Conclusions: In this multicenter cohort of admitted COVID-19 patients, receiving early interferon-β therapy after hospital admission did not show an association with lower mortality. Whether interferon-β might be useful in the earlier stages of the disease or specific subgroups of patients requires further research.
eng
COVID-19
Interferon-β
Mortality
SARS-CoV-2
Treatment
Impact of early interferon-β treatment on the prognosis of patients with COVID-19 in the first wave: A post hoc analysis from a multicenter cohort
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/14390/1/ImpactEarlyInterferon%ce%b2treatment_2021.pdf
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ImpactEarlyInterferonβtreatment_2021.pdf
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https://repisalud.isciii.es/bitstream/20.500.12105/14390/4/ImpactEarlyInterferon%ce%b2treatment_2021.pdf.txt
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ImpactEarlyInterferonβtreatment_2021.pdf.txt