2024-03-29T10:52:14Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/143202024-02-01T20:00:00Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2053com_20.500.12105_2052col_20.500.12105_16972col_20.500.12105_2054
Repisalud
author
Martínez-Horta, Saul
author
Bejr-Kasem, Helena
author
Horta-Barba, Andrea
author
Pascual-Sedano, Berta
author
Santos-García, Diego
author
de Deus-Fonticoba, Teresa
author
Jesús, Silvia
author
Aguilar, Miquel
author
Planellas, Lluis
author
García-Caldentey, Juan
author
Caballol, Nuria
author
Vives-Pastor, Bárbara
author
Hernández-Vara, Jorge
author
Cabo-Lopez, Iria
author
López-Manzanares, Lydia
author
González-Aramburu, Isabel
author
Ávila-Rivera, Maria Asunción
author
Catalán, Maria Jose
author
López-Díaz, Luis Manuel
author
Puente, Victor
author
García-Moreno, Jose Manuel
author
Borrué, Carmen
author
Solano-Vila, Berta
author
Álvarez-Sauco, Maria
author
Vela, Lydia
author
Escalante, Sonia
author
Cubo, Esther
author
Carrillo-Padilla, Francisco
author
Martínez-Castrillo, Juan Carlos
author
Sánchez-Alonso, Pilar
author
Alonso-Losada, Maria Gema
author
López-Ariztegui, Nuria
author
Gastón, Itziar
author
Blázquez-Estrada, Marta
author
Seijo-Martínez, Manual
author
Rúiz-Martínez, Javier
author
Valero-Merino, Caridad
author
Kurtis, Monica
author
de Fábregues-Boixar, Oriol
author
González-Ardura, Jessica
author
Prieto-Jurczynska, Cristina
author
Martínez-Martín, Pablo
author
Mir, Pablo
author
Kulisevsky, Jaime
author
COPPADIS Study Group
funder
Fundación Curemos el Parkinson
2022-05-09T08:22:35Z
2022-05-09T08:22:35Z
2021-12
BMC Neurol. 2021 Dec 8;21(1):477.
http://hdl.handle.net/20.500.12105/14320
34879838
10.1186/s12883-021-02485-1
1471-2377
BMC Neurology
Background:Identifying modifiable risk factors for cognitive impairment in the early stages of Parkinson’s disease (PD) and estimating their impact on cognitive status may help prevent dementia (PDD) and the design of cognitive trials. Methods: Using a standard approach for the assessment of global cognition in PD and controlling for the effects of age, education and disease duration, we explored the associations between cognitive status, comorbidities, metabolic variables and lifestyle variables in 533 PD participants from the COPPADIS study. Results:Among the overall sample, 21% of participants were classified as PD-MCI (n = 114) and 4% as PDD (n = 26). The prevalence of hypertension, diabetes and dyslipidemia was significantly higher in cognitively impaired patients while no between-group differences were found for smoking, alcohol intake or use of supplementary vitamins. Better cognitive scores were significantly associated with regular physical exercise (p < 0.05) and cognitive stimulation (< 0.01). Cognitive performance was negatively associated with interleukin 2 (Il2) (p < 0.05), Il6 (p < 0.05), iron (p < 0.05), and homocysteine (p < 0.005) levels, and positively associated with vitamin B12 levels (p < 0.005). Conclusions: We extend previous findings regarding the positive and negative influence of various comorbidities and lifestyle factors on cognitive status in early PD patients, and reinforce the need to identify and treat potentially modifiable variables with the intention of exploring the possible improvement of the global cognitive status of patients with PD.
eng
Cognition
Coppadis
Lifestyle
PD-MCI
Parkinson’s disease
Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease
journal article
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