2024-03-29T06:14:47Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/142592023-10-05T06:15:36Zcom_20.500.12105_2060com_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_2061
Repisalud
author
Vigon-Hernandez, Lorena
author
García-Pérez, Javier
author
Rodríguez-Mora, Sara
author
Torres, Montserrat
author
Mateos, Elena
author
Castillo de la Osa, María
author
Cervero, Miguel
author
Malo De Molina, Rosa
author
Navarro, Cristina
author
Murciano-Antón, María Aránzazu
author
García-Gutiérrez, Valentín
author
Planelles, Vicente
author
Alcamí, José
author
Perez-Olmeda, Mayte
author
Coiras, Mayte
author
Lopez-Huertas, Maria Rosa
author
Multidisciplinary Group of Study of COVID-19 (MGS-COVID)
funder
Instituto de Salud Carlos III
funder
Ministerio de Ciencia e Innovación (España)
funder
Ministerio de Economía y Competitividad (España)
funder
Red de Investigación Cooperativa en Investigación en Sida (España)
funder
Plan Nacional de I+D+i (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
National Institutes of Health (Estados Unidos)
2022-05-05T09:24:06Z
2022-05-05T09:24:06Z
2021-09
Front Immunol. 2021 Sep 20;12:742631.
http://hdl.handle.net/20.500.12105/14259
34616404
10.3389/fimmu.2021.742631
1664-3224
Frontiers in Immunology
SARS-CoV-2 infection causes COVID-19, ranging from mild to critical disease in symptomatic subjects. It is essential to better understand the immunologic responses occurring in patients with the most severe outcomes. In this study, parameters related to the humoral immune response elicited against SARS-CoV-2 were analysed in 61 patients with different presentations of COVID-19 who were recruited in Hospitals and Primary Healthcare Centres in Madrid, Spain, during the first pandemic peak between April and June 2020. Subjects were allocated as mild patients without hospitalization, severe patients hospitalized or critical patients requiring ICU assistance. Critical patients showed significantly enhanced levels of B cells with memory and plasmablast phenotypes, as well as higher levels of antibodies against SARS-CoV-2 with neutralization ability, which were particularly increased in male gender. Despite all this, antibody-dependent cell-mediated cytotoxicity was defective in these individuals. Besides, patients with critical COVID-19 also showed increased IgG levels against herpesvirus such as CMV, EBV, HSV-1 and VZV, as well as detectable CMV and EBV viremia in plasma. Altogether, these results suggest an enhanced but ineffectual immune response in patients with critical COVID-19 that allowed latent herpesvirus reactivation. These findings should be considered during the clinical management of these patients due to the potential contribution to the most severe disease during SARS-CoV-2 infection.
eng
CMV reactivation
COVID-19 severity
EBV reactivation
SARS-CoV-2 neutralizing antibodies
Antibody-dependent cellular cytotoxicity (ADCC)
Humoral response
Impaired Antibody-Dependent Cellular Cytotoxicity in a Spanish Cohort of Patients With COVID-19 Admitted to the ICU
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/14259/1/ImpairedAntibodyDependentCellular_2021.pdf
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ImpairedAntibodyDependentCellular_2021.pdf
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https://repisalud.isciii.es/bitstream/20.500.12105/14259/7/ImpairedAntibodyDependentCellular_2021.pdf.txt
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ImpairedAntibodyDependentCellular_2021.pdf.txt