2024-03-29T15:04:49Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/139742023-11-02T17:52:16Zcom_20.500.12105_2067com_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_2068
Repisalud
author
Schwedler, Gerda
author
Seiwert, Margarete
author
Fiddicke, Ulrike
author
Ißleb, Sissy
author
Hölzer, Jürgen
author
Nendza, Julia
author
Wilhelm, Michael
author
Wittsiepe, Jürgen
author
Koch, Holger M
author
Schindler, Birgit K
author
Göen, Thomas
author
Hildebrand, Jörg
author
Joas, Reinhard
author
Joas, Anke
author
Casteleyn, Ludwine
author
Angerer, Jürgen
author
Castaño, Argelia
author
Esteban-Lopez, Marta
author
Schoeters, Greet
author
Den Hond, Elly
author
Sepai, Ovnair
author
Exley, Karen
author
Bloemen, Louis
author
Knudsen, Lisbeth E
author
Kolossa-Gehring, Marike
funder
Unión Europea. Comisión Europea. 7 Programa Marco
funder
Federal Ministry for the Environment, Nature Conservation, Building and Nuclear Safety (Alemania)
2022-04-08T10:55:14Z
2022-04-08T10:55:14Z
2017
Int J Hyg Environ Health. 2017;220(4):686-696.
http://hdl.handle.net/20.500.12105/13974
28254163
10.1016/j.ijheh.2017.01.012
1618-131X
International Journal Of Hygiene Aand Environmental Health
Human biomonitoring (HBM) is an effective tool to assess human exposure to environmental pollutants, but comparable HBM data in Europe are lacking. In order to expedite harmonization of HBM studies on a European scale, the twin projects COPHES (Consortium to Perform Human Biomonitoring on a European Scale) and DEMOCOPHES (Demonstration of a study to Coordinate and Perform Human Biomonitoring on a European Scale) were formed, comprising 35 partners from 27 European countries. In COPHES a research scheme and guidelines were developed to exemplarily measure in a pilot study mercury in hair, cadmium, cotinine and several phthalate metabolites in urine of 6-11year old children and their mothers in an urban and a rural region. Seventeen European countries simultaneously conducted this cross-sectional DEMOCOPHES feasibility study. The German study population was taken in the city of Bochum and in the Higher Sauerland District, comprising 120 mother-child pairs. In the present paper features of the study implementation are presented. German exposure concentrations of the pollutants are reported and compared with European average concentrations from DEMOCOPHES and with those measured in the representative German Environmental Survey (GerES IV). German DEMOCOPHES concentrations for mercury and cotinine were lower than the European average. However, 47% of the children were still exposed to environmental tobacco smoke (ETS) outside their home, which gives further potential for enhancing protection of children from ETS. Compared with samples from the other European countries German participating children had lower concentrations of the phthalate metabolites MEP and of the sum of 3 DEHP-metabolites (MEHP, 5OH-MEHP and 5oxo-MEHP), about the same concentrations of the phthalate metabolites MBzP and MiBP and higher concentrations of the phthalate metabolite MnBP. 2.5% of the German children had concentrations of the sum of 4 DEHP-metabolites and 4.2% had concentrations of MnBP that exceeded health based guidance values, indicating reasons for concern. Continuous HBM is necessary to track changes of pollutant exposure over time. Therefore Germany will continue to cooperate on the harmonisation of European human biomonitoring to support the chemicals regulation with the best possible exposure data to protect Europe's people against environmental health risks.
eng
Cadmium
Cotinine
DEMOCOPHES/COPHES
Germany
Human biomonitoring
Phthalates
Mercury
Human biomonitoring pilot study DEMOCOPHES in Germany: Contribution to a harmonized European approach
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/13974/1/HumanBiomonitoringPilotStudy_2017.pdf
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https://repisalud.isciii.es/bitstream/20.500.12105/13974/5/HumanBiomonitoringPilotStudy_2017.pdf.txt
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HumanBiomonitoringPilotStudy_2017.pdf.txt