2024-03-28T08:47:54Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/138652023-07-29T01:00:40Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2053com_20.500.12105_2052col_20.500.12105_16983col_20.500.12105_16964col_20.500.12105_16962col_20.500.12105_16959col_20.500.12105_2054
Repisalud
author
Castaño-Vinyals, Gemma
author
Aragones, Nuria
author
Perez-Gomez, Beatriz
author
Martín, Vicente
author
Llorca, Javier
author
Moreno, Victor
author
Altzibar, Jone M
author
Ardanaz, Eva
author
de Sanjosé, Sílvia
author
Jimenez-Moleon, Jose J.
author
Tardón, Adonina
author
Alguacil, Juan
author
Peiró, Rosana
author
Marcos-Gragera, Rafael
author
Navarro, Carmen
author
Pollan-Santamaria, Marina
author
Kogevinas, Manolis
author
MCC-Spain Study Group
funder
Government of Spain
funder
Instituto de Salud Carlos III
funder
Fundación Marqués de Valdecilla
funder
International Cancer Genome Consortium
funder
Regional Government of Andalusia (España)
funder
Generalitat Valenciana (España)
funder
Fundación La Caixa
funder
Basque Government (España)
funder
Asociación Española Contra el Cáncer
funder
Government of Catalonia (España)
funder
Unión Europea. Comisión Europea
funder
Xarxa de Bancs de Tumors de Catalunya
2022-03-28T12:11:57Z
2022-03-28T12:11:57Z
2015-08
Gac Sanit. Jul-Aug 2015;29(4):308-15.
http://hdl.handle.net/20.500.12105/13865
25613680
10.1016/j.gaceta.2014.12.003
1578-1283
Gaceta Sanitaria
[EN] Introduction: We present the protocol of a large population-based case-control study of 5 common tumors in Spain (MCC-Spain) that evaluates environmental exposures and genetic factors. Methods: Between 2008-2013, 10,106 subjects aged 20-85 were enrolled in 23 hospitals and primary care centres in 12 Spanish provinces including 1,112 cases with a new diagnosis of prostate cancer, 1,738 of breast cancer, 2,140 of colorectal cancer, 459 of gastro-oesophageal cancer, 559 cases with chronic lymphocytic leukaemia and 4,098 population controls frequency matched to cases by age, sex and region of residence. Participation rates ranged from 57% (stomach cancer) to 87% (CLL cases) and from 30% to 77% in controls. Participants completed a face-to-face computerized interview on sociodemographic factors, environmental exposures, occupation, medication, lifestyle, and personal and family medical history. In addition, participants completed a self-administered food-frequency questionnaire and telephone interviews. Blood samples were collected from 76% of participants while saliva samples were collected in CLL cases and participants refusing blood extractions. Clinical information was recorded for cases and paraffin blocks and/or fresh tumor samples are available in most collaborating hospitals. Genotyping was done through an exome array enriched with genetic markers in specific pathways. Multiple analyses are planned to assess the association of environmental, personal and genetic risk factors for each tumor and to identify pleiotropic effects. Discussion: This study, conducted within the Spanish Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), is a unique initiative to evaluate etiological factors for common cancers and will promote cancer research and prevention in Spain. [ES] Introducción: Presentamos el protocolo del estudio caso-control de base poblacional de 5 tumores comunes en España (MCC-Spain) que evalúa factores ambientales y genéticos. Métodos: Durante 2008-2013, se reclutaron 10.183 sujetos entre 20-85 años en 23 hospitales de 12 provincias españolas, incluyendo 1.115 casos de cáncer de próstata, 1.750 de mama, 2.171 colorrectal, 492 gastro-esofágicos, 554 de leucemia linfática crónica (LLC) y 4.101 controles poblacionales emparejados por frecuencia por edad, sexo y región de residencia. Las tasas de participación varían del 57% (cáncer de estómago) al 87% (casos de LLC) y del 30% al 77% en controles. Los participantes respondieron una entrevista personal informatizada sobre factores socio-demográficos, exposiciones ambientales, ocupación, medicación, estilos de vida, e historia médica personal y familiar. Además, cumplimentaron un cuestionario alimentario y realizaron entrevistas telefónicas. Se recogió sangre del 76% de los participantes y saliva para los casos de LLC y participantes que rechazaron la donación de sangre. En los casos, se recogió información clínica y se dispone de muestras de tumor fresco o parafinado a través de los biobancos de los hospitales. Se realizó el genotipado con un array de exoma suplementado con marcadores en pathways específicos. Se han planificado diversos análisis para evaluar la asociación de factores genéticos, personales y ambientales para cada tumor e identificar efectos pleiotrópicos. Discusión: Este estudio, desarrollado en el Consorcio de Investigación Biomédica de Epidemiología y Salud Pública (CIBERESP), es una iniciativa única para evaluar factores etiológicos de tumores comunes y promoverá la investigación en cáncer y prevención en España.
eng
Case-control
Epidemiology
Colorectal cancer
Prostate cancer
Breast cancer
Gastric cancer
Chronic lymphocytic leukemia
Caso-control
Epidemiología
Cáncer colorrectal
Cáncer de próstata
Cáncer de mama
Cáncer gástrico
Leucemia linfática crónica
Population-based multicase-control study in common tumors in Spain (MCC-Spain): rationale and study design
journal article
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