2024-03-28T15:36:02Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/126942022-11-07T10:58:12Zcom_20.500.12105_2060com_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_2061
Repisalud
author
Richi, Patricia
author
Yuste, Jose Enrique
author
Navío, Teresa
author
González-Hombrado, Laura
author
Salido, Marina
author
Thuissard-Vasallo, Israel
author
Jiménez-Díaz, Ana
author
Llorente, Jesús
author
Cebrián, Laura
author
Lojo, Leticia
author
Steiner, Martina
author
Cobo, Tatiana
author
Martín, María Dolores
author
García-Castro, Marta
author
Castro, Patricia
author
Muñoz-Fernández, Santiago
funder
Sociedad Madrileña de Reumatología
funder
Ministerio de Economía, Industria y Competitividad (España)
2021-04-20T09:03:09Z
2021-04-20T09:03:09Z
2021-02-28
Vaccines (Basel). 2021 Feb 28;9(3):203.
2076-393X
http://hdl.handle.net/20.500.12105/12694
33671007
10.3390/vaccines9030203
Vaccines
Patients with different autoimmune inflammatory diseases (AIID) on biological therapy are at risk of pneumococcal disease. Adults with inflammatory arthropathies, connective tissue diseases, psoriasis, or inflammatory bowel disease on biological therapy such as anti-TNFα, rituximab, tocilizumab, abatacept, or anakinra were included in this study. Patients completed a protocol combining the pneumococcal vaccines PCV13 and PPV23. Immune response against pneumococcal serotypes 1, 3, 7F, 14, 19A, and 19F were assessed evaluating functional antibodies by an opsonophagocytosis killing assay (OPKA). In this study, 182 patients with AIID completed the sequential vaccination protocol. Patients on etanercept tended to achieve OPKA titers against a larger number of serotypes than the rest of patients on other biological therapies, while adalimumab was associated to a lower number of serotypes with OPKA titers. Rituximab was not associated with a worse response when compared with the rest of biological agents. Not glucocorticoids, nor synthetic disease-modifying antirheumatic drugs, interfered with the immune response. OPKA titers against serotype 3 which is one of the most prevalent, was obtained in 44% of patients, increasing up to 58% in those on etanercept. Hence, almost 50% of patients on biological therapy achieved functional antibodies after the administration of a complete pneumococcal vaccination protocol.
eng
OPKA titers
PCV13
PPV23
anti-TNFα
Autoimmune inflammatory diseases
Biological therapy
Invasive pneumococcal disease
Rituximab
Tocilizumab
Impact of Biological Therapies on the Immune Response after Pneumococcal Vaccination in Patients with Autoimmune Inflammatory Diseases.
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/12694/1/ImpactOfBiologicalTherapies_2021.pdf
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ImpactOfBiologicalTherapies_2021.pdf
URL
https://repisalud.isciii.es/bitstream/20.500.12105/12694/4/ImpactOfBiologicalTherapies_2021.pdf.txt
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MD5
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ImpactOfBiologicalTherapies_2021.pdf.txt