2024-03-29T13:53:00Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/125952022-10-13T12:20:32Zcom_20.500.12105_2053com_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_2054
Repisalud
author
Gómez-Acebo, Inés
author
Dierssen-Sotos, Trinidad
author
Mirones, Mónica
author
Perez-Gomez, Beatriz
author
Guevara, Marcela
author
Amiano, Pilar
author
Sala, María
author
Molina, Antonio J
author
Alonso-Molero, Jéssica
author
Moreno, Victor
author
Suarez-Calleja, Claudia
author
Molina-Barceló, Ana
author
Alguacil, Juan
author
Marcos-Gragera, Rafael
author
Fernández-Ortiz, María
author
Sanz-Guadarrama, Oscar
author
Castaño-Vinyals, Gemma
author
Gil-Majuelo, Leire
author
Moreno-Iribas, Conchi
author
Aragones, Nuria
author
Kogevinas, Manolis
author
Pollan-Santamaria, Marina
author
Llorca, Javier
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Fundación Marqués de Valdecilla
funder
Junta de Castilla y León (España)
funder
Regional Government of Andalusia (España)
funder
Generalitat Valenciana (España)
funder
Fundación La Caixa
funder
Basque Government (España)
funder
Gobierno de la Región de Murcia (España)
funder
Unión Europea. Comisión Europea
funder
Asociación Española Contra el Cáncer
funder
Government of Catalonia (España)
funder
Fundación Caja de Ahorros de Asturias
funder
University of Oviedo (España)
funder
Societat Catalana de Digestologia
2021-04-11T12:11:09Z
2021-04-11T12:11:09Z
2021-03-08
Sci Rep. 2021 Mar 8;11(1):5375.
http://hdl.handle.net/20.500.12105/12595
33686151
10.1038/s41598-021-84825-2
2045-2322
Scientific reports
The St Gallen Conference endorsed in 2013 a series of recommendations on early breast cancer treatment. The main purpose of this article is to ascertain the clinical factors associated with St Gallen-2013 recommendations accomplishment. A cohort of 1152 breast cancer cases diagnosed with pathological stage < 3 in Spain between 2008 and 2013 was begun and then followed-up until 2017/2018. Data on patient and tumour characteristics were obtained from medical records, as well as their first line treatment. First line treatments were classified in three categories, according on whether they included the main St Gallen-2013 recommendations, more than those recommended or less than those recommended. Multinomial logistic regression models were carried out to identify factors associated with this classification and Weibull regression models were used to find out the relationship between this classification and survival. About half of the patients were treated according to St Gallen recommendations; 21% were treated over what was recommended and 33% received less treatment than recommended. Factors associated with treatment over the recommendations were stage II (relative risk ratio [RRR] = 4.2, 2.9-5.9), cancer positive to either progesterone (RRR = 8.1, 4.4-14.9) or oestrogen receptors (RRR = 5.7, 3.0-11.0). Instead, factors associated with lower probability of treatment over the recommendations were age (RRR = 0.7 each 10 years, 0.6-0.8), poor differentiation (RRR = 0.09, 0.04-0.19), HER2 positive (RRR = 0.46, 0.26-0.81) and triple negative cancer (RRR = 0.03, 0.01-0.11). Patients treated less than what was recommended in St Gallen had cancers in stage 0 (RRR = 21.6, 7.2-64.5), poorly differentiated (RRR = 1.9, 1.2-2.9), HER2 positive (RRR = 3.4, 2.4-4.9) and luminal B-like subtype (RRR = 3.6, 2.6-5.1). Women over 65 years old had a higher probability of being treated less than what was recommended if they had luminal B-like, HER2 or triple negative cancer. Treatment over St Gallen was associated with younger women and less severe cancers, while treatment under St Gallen was associated with older women, more severe cancers and cancers expressing HER2 receptors.
eng
Cancer
Health care
Medical research
Oncology
Risk factors
Adequacy of early-stage breast cancer systemic adjuvant treatment to Saint Gallen-2013 statement: the MCC-Spain study.
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/12595/1/AdequacyOfEarlyStage_2021.pdf
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https://repisalud.isciii.es/bitstream/20.500.12105/12595/6/AdequacyOfEarlyStage_2021.pdf.txt
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AdequacyOfEarlyStage_2021.pdf.txt