2024-03-29T09:51:18Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/116162022-11-22T13:57:10Zcom_20.500.12105_2053com_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_2054
Repisalud
author
Hong, Yun Soo
author
Ryu, Seungho
author
Chang, Yoosoo
author
Caínzos-Achirica, Miguel
author
Kwon, Min-Jung
author
Zhao, Di
author
Shafi, Tariq
author
Lazo, Mariana
author
Pastor-Barriuso, Roberto
author
Shin, Hocheol
author
Cho, Juhee
author
Guallar, Eliseo
2021-01-15T09:03:55Z
2021-01-15T09:03:55Z
2018
BMC Nephrol . 2018 Dec 11;19(1):353. d
http://hdl.handle.net/20.500.12105/11616
30537940
10.1186/s12882-018-1154-4
1471-2369
BMC nephrology
The effect of chronic hepatitis B virus (HBV) infection on the risk of chronic kidney disease (CKD) is controversial. We examined the prospective association between hepatitis B surface antigen (HBsAg) serology status and incident CKD in a large cohort of men and women.
Cohort study of 299,913 adults free of CKD at baseline who underwent health screening exams between January 2002 and December 2016 in South Korea. Incident CKD was defined as the development of an estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73m2 and/or proteinuria.
Over 1,673,701 person-years of follow-up, we observed 13,924 incident cases of CKD (3225 cases of eGFR < 60 ml/min/1.73m2 and 11,072 cases of proteinuria). In fully adjusted models comparing positive to negative HBsAg participants, the hazard ratio (HR, 95% confidence interval) for incident CKD was 1.11 (1.03-1.21; P = 0.01). The corresponding HR for incident proteinuria and for eGFR < 60 ml/min/1.73m2 were 1.23 (1.12-1.35; P < 0.001) and 0.89 (0.73-1.07; P = 0.21), respectively. The associations were similar across categories of liver enzyme levels at baseline.
In this large cohort, HBsAg positive serology was associated with higher risk of incident CKD, and we provide novel evidence that this association was due to a higher incidence of proteinuria in HBsAg positive participants. Our study adds to the growing body of evidence suggesting that chronic HBV infection may be a contributor to the increasing incidence of CKD.
eng
Hepatitis B virus infection and development of chronic kidney disease: a cohort study.
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/11616/1/HepatitisBVirusInfection_2018.pdf
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/11616/4/HepatitisBVirusInfection_2018.pdf.txt
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HepatitisBVirusInfection_2018.pdf.txt