2024-03-29T14:59:08Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/114362023-09-21T10:27:16Zcom_20.500.12105_2060com_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_2061
Repisalud
author
Muzzi, Alessandro
author
Brozzi, Alessandro
author
Serino, Laura
author
Bodini, Margherita
author
Abad, Raquel
author
Caugant, Dominique
author
Comanducci, Maurizio
author
Lemos, Ana Paula
author
Gorla, Maria Cecilia
author
Křížová, Pavla
author
Mikula, Claudia
author
Mulhall, Robert
author
Nissen, Michael
author
Nohynek, Hanna
author
Simões, Maria João
author
Skoczyńska, Anna
author
Stefanelli, Paola
author
Taha, Muhamed-Kheir
author
Toropainen, Maija
author
Tzanakaki, Georgina
author
Vadivelu-Pechai, Kumaran
author
Watson, Philip
author
Vazquez-Moreno, Julio Alberto
author
Rajam, Gowrisankar
author
Rappuoli, Rino
author
Borrow, Ray
author
Medini, Duccio
funder
GlaxoSmithKline
2020-11-26T09:01:57Z
2020-11-26T09:01:57Z
2019
Vaccine. 2019 Feb 8;37(7):991-1000.
0264-410X
http://hdl.handle.net/20.500.12105/11436
30661831
10.1016/j.vaccine.2018.12.061
1873-2518
Vaccine
The Meningococcal Antigen Typing System (MATS) was developed to identify meningococcus group B strains with a high likelihood of being covered by the 4CMenB vaccine, but is limited by the requirement for viable isolates from culture-confirmed cases. We examined if antigen genotyping could complement MATS in predicting strain coverage by the 4CMenB vaccine.
From a panel of 3912 MATS-typed invasive meningococcal disease isolates collected in England and Wales in 2007-2008, 2014-2015 and 2015-2016, and in 16 other countries in 2000-2015, 3481 isolates were also characterized by antigen genotyping. Individual associations between antigen genotypes and MATS coverage for each 4CMenB component were used to define a genetic MATS (gMATS). gMATS estimates were compared with England and Wales human complement serum bactericidal assay (hSBA) data and vaccine effectiveness (VE) data from England.
Overall, 81% of the strain panel had genetically predictable MATS coverage, with 92% accuracy and highly concordant results across national panels (Lin's accuracy coefficient, 0.98; root-mean-square deviation, 6%). England and Wales strain coverage estimates were 72-73% by genotyping (66-73% by MATS), underestimating hSBA values after four vaccine doses (88%) and VE after two doses (83%). The gMATS predicted strain coverage in other countries was 58-88%.
gMATS can replace MATS in predicting 4CMenB strain coverage in four out of five cases, without requiring a cultivable isolate, and is open to further improvement. Both methods underestimated VE in England. Strain coverage predictions in other countries matched or exceeded England and Wales estimates.
eng
Genetic Meningococcal Antigen Typing System (gMATS): A genotyping tool that predicts 4CMenB strain coverage worldwide
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/11436/1/GeneticMeningococcalAntigenTyping_2019.pdf
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GeneticMeningococcalAntigenTyping_2019.pdf
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https://repisalud.isciii.es/bitstream/20.500.12105/11436/2/GeneticMeningococcalAntigenTyping_2019%20mat%20suppl.pdf
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GeneticMeningococcalAntigenTyping_2019 mat suppl.pdf
URL
https://repisalud.isciii.es/bitstream/20.500.12105/11436/9/GeneticMeningococcalAntigenTyping_2019.pdf.txt
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GeneticMeningococcalAntigenTyping_2019.pdf.txt
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https://repisalud.isciii.es/bitstream/20.500.12105/11436/11/GeneticMeningococcalAntigenTyping_2019%20mat%20suppl.pdf.txt
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GeneticMeningococcalAntigenTyping_2019 mat suppl.pdf.txt