2024-03-29T07:39:49Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/111892023-04-19T12:33:14Zcom_20.500.12105_2145com_20.500.12105_2051com_20.500.12105_2144col_20.500.12105_2146
Repisalud
author
Rossello, Xavier
author
Fuster, Valentin
author
Oliva, Belen
author
Sanz, Javier
author
Fernandez-Friera, Leticia
author
Lopez-Melgar, Beatriz
author
Mendiguren, Jose M
author
Lara-Pezzi, Enrique
author
Bueno, Hector
author
Fernandez-Ortiz, Antonio
author
Ibáñez, Borja
author
Ordovas, Jose M
funder
Centro Nacional de Investigaciones Cardiovasculares Carlos III (España)
funder
Banco Santander
funder
Instituto de Salud Carlos III
funder
European Regional Development Fund
funder
Fundación ProCNIC
2020-10-21T11:00:43Z
2020-10-21T11:00:43Z
2020-12-01
J Clin Endocrinol Metab. 2020; 105(12):dgaa620
http://hdl.handle.net/20.500.12105/11189
32879953
10.1210/clinem/dgaa620
1945-7197
The Journal of clinical endocrinology and metabolism
The underlying relationship between body mass index (BMI), cardiometabolic disorders, and subclinical atherosclerosis is poorly understood.
To evaluate the association between body size phenotypes and subclinical atherosclerosis.
Cross-sectional.
Cardiovascular disease-free cohort.
Middle-aged asymptomatic subjects (n = 3909). A total of 6 cardiometabolic body size phenotypes were defined based on the presence of at least 1 cardiometabolic abnormality (blood pressure, fasting blood glucose, triglycerides, low high-density lipoprotein cholesterol, homeostasis model assessment-insulin resistance index, high-sensitivity C-reactive protein) and based on BMI: normal-weight (NW; BMI <25), overweight (OW; BMI = 25.0-29.9) or obese (OB; BMI >30.0).
Subclinical atherosclerosis was evaluated by 2D vascular ultrasonography and noncontrast cardiac computed tomography.
For metabolically healthy subjects, the presence of subclinical atherosclerosis increased across BMI categories (49.6%, 58.0%, and 67.7% for NW, OW, and OB, respectively), whereas fewer differences were observed for metabolically unhealthy subjects (61.1%, 69.7%, and 70.5%, respectively). When BMI and cardiometabolic abnormalities were assessed separately, the association of body size phenotypes with the extent of subclinical atherosclerosis was mostly driven by the coexistence of cardiometabolic risk factors: adjusted OR = 1.04 (95% confidence interval [CI], 0.90-1.19) for OW and OR = 1.07 (95% CI, 0.88-1.30) for OB in comparison with NW, whereas there was an increasing association between the extent of subclinical atherosclerosis and the number of cardiometabolic abnormalities: adjusted OR = 1.21 (95% CI, 1.05-1.40), 1.60 (95% CI, 1.33-1.93), 1.92 (95% CI, 1.48-2.50), and 2.27 (95% CI, 1.67-3.09) for 1, 2, 3, and >3, respectively, in comparison with noncardiometabolic abnormalities.
The prevalence of subclinical atherosclerosis varies across body size phenotypes. Pharmacologic and lifestyle interventions might modify their cardiovascular risk by facilitating the transition from one phenotype to another.
eng
Association Between Body Size Phenotypes and Subclinical Atherosclerosis.
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/11189/1/AssociationBetweenBodySize_2020.pdf
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https://repisalud.isciii.es/bitstream/20.500.12105/11189/6/AssociationBetweenBodySize_2020.pdf.txt
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