2024-03-29T06:33:58Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/106572023-10-09T08:45:52Zcom_20.500.12105_2060com_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_2061
Repisalud
author
Rico, Miguel Angel
author
Trento, Alfonsina
author
Melero, Jose Antonio
author
Infantes, Susana
author
Ramos, Manuel
author
Johnstone, Carolina
author
Val, Margarita del
author
Lopez, Daniel
funder
Ministerio de Educación y Ciencia (España)
funder
Comunidad de Madrid (España)
funder
Instituto de Salud Carlos III
2020-07-06T05:55:56Z
2020-07-06T05:55:56Z
2010-05
Mol Immunol . 2010 May;47(9):1802-7.
0161-5890
http://hdl.handle.net/20.500.12105/10657
20362337
10.1016/j.molimm.2010.02.019
1872-9142
Molecular immunology
Human respiratory syncytial virus (HRSV) is the most common cause of severe respiratory infections in infants and young children, often leading to hospitalization. In addition, HRSV poses a serious health risk in immunocompromised individuals and the elderly. It has been reported that this virus can infect mouse antigen-presenting cells, including B lymphocytes. In these B cells, HRSV infection upregulates the expression of activation markers, including MHC class II and CD86, but not MHC class I molecules. Here, we report that HRSV infection of spleen B lymphocytes downregulated TLR4. Either blocking with anti-TLR4 antibody or genetic deletion, but not functional deficiency of TLR4, moderately reduced the infectivity of HRSV in B lymphocytes. HRSV-infected B lymphocytes with deleted TLR4 upregulated MHC class II and CD86 molecules to the same levels as TLR4(+) wild type B cells. Since the activation of monocytes and macrophages by HRSV was previously reported to depend on TLR4, the current study indicates that these cells and B lymphocytes respond to HRSV infection with different activation pathways.
eng
TLR4-independent upregulation of activation markers in mouse B lymphocytes infected by HRSV.
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/10657/1/TLR4IndependentUpregulationOf_2010.pdf
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TLR4IndependentUpregulationOf_2010.pdf
URL
https://repisalud.isciii.es/bitstream/20.500.12105/10657/8/TLR4IndependentUpregulationOf_2010.pdf.txt
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TLR4IndependentUpregulationOf_2010.pdf.txt