2024-03-28T10:57:40Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/103942022-10-06T12:50:17Zcom_20.500.12105_2060com_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_2061
Repisalud
author
Riquelme, Paloma
author
Haarer, Jan
author
Kammler, Anja
author
Walter, Lisa
author
Tomiuk, Stefan
author
Ahrens, Norbert
author
Wege, Anja K
author
Goecze, Ivan
author
Zecher, Daniel
author
Banas, Bernhard
author
Spang, Rainer
author
Fändrich, Fred
author
Lutz, Manfred B
author
Sawitzki, Birgit
author
Schlitt, Hans J
author
Ochando, Jordi
author
Geissler, Edward K
author
Hutchinson, James A
funder
Unión Europea. Comisión Europea. 7 Programa Marco
funder
Deutsche Forschungsgemeinschaft (Alemania)
funder
Unión Europea. Comisión Europea. H2020
2020-06-15T06:20:40Z
2020-06-15T06:20:40Z
2018
Nat Commun . 2018 Jul 20;9(1):2858.
http://hdl.handle.net/20.500.12105/10394
30030423
10.1038/s41467-018-05167-8
2041-1723
Nature communications
Human regulatory macrophages (Mreg) have shown early clinical promise as a cell-based adjunct immunosuppressive therapy in solid organ transplantation. It is hypothesised that recipient CD4+ T cell responses are actively regulated through direct allorecognition of donor-derived Mregs. Here we show that human Mregs convert allogeneic CD4+ T cells to IL-10-producing, TIGIT+ FoxP3+-induced regulatory T cells that non-specifically suppress bystander T cells and inhibit dendritic cell maturation. Differentiation of Mreg-induced Tregs relies on multiple non-redundant mechanisms that are not exclusive to interaction of Mregs and T cells, including signals mediated by indoleamine 2,3-dioxygenase, TGF-β, retinoic acid, Notch and progestagen-associated endometrial protein. Preoperative administration of donor-derived Mregs to living-donor kidney transplant recipients results in an acute increase in circulating TIGIT+ Tregs. These results suggest a feed-forward mechanism by which Mreg treatment promotes allograft acceptance through rapid induction of direct-pathway Tregs.
eng
TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity.
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/10394/1/TIGIT%2biTregsElicitedBy_2018.pdf
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TIGIT+iTregsElicitedBy_2018.pdf
URL
https://repisalud.isciii.es/bitstream/20.500.12105/10394/6/TIGIT%2biTregsElicitedBy_2018.pdf.txt
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TIGIT+iTregsElicitedBy_2018.pdf.txt