2024-03-28T15:58:19Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/102352023-10-17T07:32:50Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2053com_20.500.12105_2052col_20.500.12105_16984col_20.500.12105_2054
Repisalud
author
Domingo-Relloso, Arce
author
Grau-Perez, Maria
author
Galan-Chilet, Inmaculada
author
Garrido-Martinez, Maria J
author
Tormos, Carmen
author
Navas-Acien, Ana
author
Gomez-Ariza, Jose L
author
Monzo-Beltran, Lidia
author
Saez-Tormo, Guillermo
author
Garcia-Barrera, Tamara
author
Dueñas Laita, Antonio
author
Briongos Figuero, Laisa S
author
Martin-Escudero, Juan C
author
Chaves, F Javier
author
Redon, Josep
author
Tellez-Plaza, Maria
funder
Generalitat Valenciana (España)
funder
Junta de Castilla y León (España)
funder
European Network of Excellence EUROPRISE
funder
Redes Temáticas de Investigación Cooperativa en Salud (RETICS) (España)
funder
Centro de Investigación Biomedica en Red - CIBER
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2020-06-01T07:56:13Z
2020-06-01T07:56:13Z
2019
Environ Int . 2019 Feb;123:171-180.
0160-4120
http://hdl.handle.net/20.500.12105/10235
30529889
10.1016/j.envint.2018.11.055
1873-6750
Environment international
Few studies have investigated the role of exposure to metals and metal mixtures on oxidative stress in the general population.
We evaluated the cross-sectional association of urinary metal and metal mixtures with urinary oxidative stress biomarkers, including oxidized to reduced glutathione ratio (GSSG/GSH), malondialdehyde (MDA), and 8‑oxo‑7,8‑dihydroguanine (8-oxo-dG), in a representative sample of a general population from Spain (Hortega Study).
Urine antimony (Sb), barium (Ba), cadmium (Cd), chromium (Cr), cobalt (Co), copper (Cu), molybdenum (Mo), vanadium (V) and zinc (Zn) were measured by ICPMS in 1440 Hortega Study participants.
The geometric mean ratios (GMRs) of GSSG/GSH comparing the 80th to the 20th percentiles of metal distributions were 1.15 (95% confidence intervals [95% CI]: 1.03-1.27) for Mo, 1.17 (1.05-1.31) for Ba, 1.23 (1.04-1.46) for Cr and 1.18 (1.00-1.40) for V. For MDA, the corresponding GMRs (95% CI) were 1.13 (1.03-1.24) for Zn and 1.12 (1.02-1.23) for Cd. In 8-oxo-dG models, the corresponding GMR (95% CI) were 1.12 (1.01-1.23) for Zn and 1.09 (0.99-1.20) for Cd. Cr for GSSG/GSH and Zn for MDA and 8-oxo-dG drove most of the observed associations. Principal component (PC) 1 (largely reflecting non-essential metals) was positively associated with GSSG/GSH. The association of PC2 (largely reflecting essential metals) was positive for GSSG/GSH but inverse for MDA.
Urine Ba, Cd, Cr, Mo, V and Zn were positively associated with oxidative stress measures at metal exposure levels relevant for the general population. The potential health consequences of environmental, including nutritional, exposure to these metals warrants further investigation.
eng
Urinary metals and metal mixtures and oxidative stress biomarkers in an adult population from Spain: The Hortega Study.
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/10235/1/UrinaryMetalsAndMetal_2019.pdf
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https://repisalud.isciii.es/bitstream/20.500.12105/10235/6/UrinaryMetalsAndMetal_2019.pdf.txt
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