2024-03-29T11:28:07Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/89352023-10-16T11:58:45Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2053com_20.500.12105_2052col_20.500.12105_16983col_20.500.12105_16974col_20.500.12105_16970col_20.500.12105_16968col_20.500.12105_16962col_20.500.12105_16959col_20.500.12105_2054
00925njm 22002777a 4500
dc
Vallès, Xavier
author
Alonso, M Henar
author
López-Caleya, Juan Francisco
author
Díez-Obrero, Virginia
author
Dierssen-Sotos, Trinidad
author
Lope Carvajal, Virginia
author
Molina-Barceló, Ana
author
Chirlaque, María Dolores
author
Jimenez-Moleon, Jose J.
author
Fernández Tardón, Guillermo
author
Castilla Catalán, Jesús
author
Amiano, Pilar
author
Capelo, Rocío
author
Castaño-Vinyals, Gemma
author
Guinó, Elisabet
author
Molina de la Torre, Antonio José
author
Moreno-Iribas, Conchi
author
Perez-Gomez, Beatriz
author
Aragones, Nuria
author
Llorca, Javier
author
Martín, Vicente
author
Kogevinas, Manolis
author
Pollan-Santamaria, Marina
author
Moreno, Victor
author
2018
OBJECTIVES: To explore the association of colorectal cancer with environmental solar radiation and sun exposure behavior, considering phenotypic variables (eye color, hair color and skin phenotype), dietary intake of vitamin D and calcium, and socio-demographic factors. STUDY DESIGN: Multicenter population-based frequency matched case-control study in Spain (MCC-Spain), with 2140 CRC cases and 3950 controls. METHODS: Data were obtained through personal interviews using a structured epidemiological questionnaire that included socio-demographic data, residential history, environmental exposures, behavior, phenotypic and dietary information. An environmental-lifetime sun exposure score was constructed combining residential history and average daily solar radiation, direct and diffuse. Logistic regression was used to explore the association between different variables. A structural equation model was used to verify the associations of the conceptual model. RESULTS: We found a lower risk of CRC in subjects frequently exposed to sunlight during the previous summer and skin burning due to sun exposure. No association was observed in relation to the residential solar radiation scores. Subjects with light eye or light hair colors had a lower risk of CRC that those with darker colors. Dietary calcium and vitamin D were also protective factors, but not in the multivariate model. The structural equation model analysis suggested that higher sun exposure was associated with a decreased risk of CRC, as well as dietary intake of calcium and vitamin D, and these factors are correlated among themselves and with environmental solar radiation and skin phenotypes. CONCLUSION: The results agree with previous observations that sun exposure, dietary vitamin D and calcium intake, and serum 25(OH)D concentration reduce the risk of CRC and indicate that these factors may be relevant for cancer prevention.
Environ Int. 2018 Dec;121(Pt 1):428-434.
0160-4120
http://hdl.handle.net/20.500.12105/8935
30266013
10.1016/j.envint.2018.09.030
1873-6750
Environment international
Calcium
Colorectal cancer
Skin phenotype
Sunlight
Vitamin D
Colorectal cancer, sun exposure and dietary vitamin D and calcium intake in the MCC-Spain study