2024-03-28T14:55:14Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/88252023-10-16T12:17:25Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2053com_20.500.12105_2052col_20.500.12105_16983col_20.500.12105_16981col_20.500.12105_16970col_20.500.12105_16968col_20.500.12105_16967col_20.500.12105_16962col_20.500.12105_2054
00925njm 22002777a 4500
dc
Vitelli Storelli, Facundo
author
Molina, Antonio José
author
Zamora-Ros, Raúl
author
Fernández-Villa, Tania
author
Roussou, Vasiliki
author
Romaguera, Dora
author
Aragones, Nuria
author
Obón-Santacana, Mireia
author
Guevara, Marcela
author
Gómez-Acebo, Inés
author
Fernández-Tardón, Guillermo
author
Molina-Barceló, Ana
author
Olmedo-Requena, Rocío
author
Capelo, Rocío
author
Chirlaque, María Dolores
author
Perez-Gomez, Beatriz
author
Moreno, Victor
author
Castilla Catalán, Jesús
author
Rubín-García, María
author
Pollan-Santamaria, Marina
author
Kogevinas, Manolis
author
Lera, Juan Pablo Barrio
author
Martín, Vicente
author
2019-04-27
Several epidemiological studies have investigated the association between the dietary flavonoid intake and gastric cancer (GC) risk; however, the results remain inconclusive. Investigating the relationship between the different classes of flavonoids and the histological types and origin of GC can be of interest to the research community. We used data from a population-based multi-case control study (MCC-Spain) obtained from 12 different regions of Spain. 2700 controls and 329 GC cases were included in this study. Odds ratios (ORs) were calculated using the mixed effects logistic regression considering quartiles of flavonoid intakes and log2. Flavonoid intake was associated with a lower GC risk (ORlog2 = 0.76; 95% CI = 0.65-0.89; ORq4vsq1 = 0.60; 95%CI = 0.40-0.89; ptrend = 0.007). Inverse and statistically significant associations were observed with anthocyanidins, chalcones, dihydroflavonols and flavan-3-ols. The isoflavanoid intake was positively associated with higher cancer risk, but without reaching a statistical significance. In general, no differences were observed in the GC risk according to the location and histological type. The flavonoid intake seems to be a protective factor against GC within the MCC-study. This effect may vary depending on the flavonoid class but not by the histological type and location of the tumor. Broader studies with larger sample size and greater geographical variability are necessary.
Nutrients. 2019 Apr 27;11(5). pii: E967.
2072-6643
http://hdl.handle.net/20.500.12105/8825
31035601
10.3390/nu11050967
2072-6643
Nutrients
MCC-Spain
Case-control study
Flavonoids
Gastric cancer
Intake
Flavonoids and the Risk of Gastric Cancer: An Exploratory Case-Control Study in the MCC-Spain Study