2024-03-28T19:13:39Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/87152023-10-11T06:47:28Zcom_20.500.12105_2053com_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_2054
00925njm 22002777a 4500
dc
Gómez-Acebo, Inés
author
Dierssen-Sotos, Trinidad
author
Palazuelos, Camilo
author
Fernandez-Navarro, Pablo L
author
Castaño-Vinyals, Gemma
author
Alonso-Molero, Jéssica
author
Urtiaga, Carmen
author
Fernández-Villa, Tania
author
Ardanaz, Eva
author
Rivas-Del-Fresno, Manuel
author
Molina-Barceló, Ana
author
Jimenez-Moleon, Jose J.
author
García-Martinez, Lidia
author
Amiano, Pilar
author
Rodríguez-Cundín, Paz
author
Moreno, Víctor
author
Perez-Gomez, Beatriz
author
Aragones, Nuria
author
Kogevinas, Manolis
author
Pollan-Santamaria, Marina
author
Llorca, Javier
author
2018
INTRODUCTION: Phototype has been associated with an increased risk of prostate cancer, and it is yet unknown if it is related to other hormone-dependent cancers, such as breast cancer or whether this association could be considered causal. METHODS: We examined the association between the phototype and breast and prostate cancers using a Mendelian randomization analysis. We studied 1,738 incident cases of breast cancer and another 817 cases of prostate cancer. To perform a Mendelian randomization analysis on the phototype-cancer relationship, a genetic pigmentation score was required that met the following criteria: (1) the genetic pigmentation score was associated with phototype in controls; (2) the genetic pigmentation score was not associated with confounders in the relationship between phototype and cancer, and (3) the genetic pigmentation score was associated with cancer only through its association with phototype. Once this genetic score is available, the association between genetic pigmentation score and cancer can be identified as the association between phototype and cancer. RESULTS: The association between the genetic pigmentation score and phototype in controls showed that a higher genetic pigmentation score was associated with fair skin, blond hair, blue eyes and the presence of freckles. Applying the Mendelian randomization analysis, we verified that there was no association between the genetic pigmentation score and cancers of the breast and prostate. CONCLUSIONS: Phototype is not associated with breast or prostate cancer.
PLoS One. 2018 Aug 14;13(8):e0201750.
1932-6203
http://hdl.handle.net/20.500.12105/8715
30106959
10.1371/journal.pone.0201750
1932-6203
PloS one
Pigmentation phototype and prostate and breast cancer in a select Spanish population-A Mendelian randomization analysis in the MCC-Spain study