2024-03-28T17:46:18Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/85652023-02-15T08:12:45Zcom_20.500.12105_2060com_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_2061
00925njm 22002777a 4500
dc
Conde-San Román, Patricia
author
Rodriguez-Garcia, Mercedes
author
van der Touw, William
author
Jimenez, Ana
author
Burns, Matthew
author
Miller, Jennifer
author
Brahmachary, Manisha
author
Chen, Hui-ming
author
Boros, Peter
author
Rausell-Palamos, Francisco
author
Yun, Tae Jin
author
Riquelme, Paloma
author
Rastrojo, Alberto
author
Aguado, Begoña
author
Stein-Streilein, Joan
author
Tanaka, Masato
author
Zhou, Lan
author
Zhang, Junfeng
author
Lowary, Todd L
author
Ginhoux, Florent
author
Park, Chae Gyu
author
Cheong, Cheolho
author
Brody, Joshua
author
Turley, Shannon J
author
Lira, Sergio A
author
Bronte, Vincenzo
author
Gordon, Siamon
author
Heeger, Peter S
author
Merad, Miriam
author
Hutchinson, James
author
Chen, Shu-Hsia
author
Ochando, Jordi
author
2015-06-16
Tissue effector cells of the monocyte lineage can differentiate into different cell types with specific cell function depending on their environment. The phenotype, developmental requirements, and functional mechanisms of immune protective macrophages that mediate the induction of transplantation tolerance remain elusive. Here, we demonstrate that costimulatory blockade favored accumulation of DC-SIGN-expressing macrophages that inhibited CD8(+) T cell immunity and promoted CD4(+)Foxp3(+) Treg cell expansion in numbers. Mechanistically, that simultaneous DC-SIGN engagement by fucosylated ligands and TLR4 signaling was required for production of immunoregulatory IL-10 associated with prolonged allograft survival. Deletion of DC-SIGN-expressing macrophages in vivo, interfering with their CSF1-dependent development, or preventing the DC-SIGN signaling pathway abrogated tolerance. Together, the results provide new insights into the tolerogenic effects of costimulatory blockade and identify DC-SIGN(+) suppressive macrophages as crucial mediators of immunological tolerance with the concomitant therapeutic implications in the clinic.
Immunity. 2015 Jun 16;42(6):1143-58.
1074-7613
http://hdl.handle.net/20.500.12105/8565
26070485
10.1016/j.immuni.2015.05.009
1097-4180
Immunity
DC-SIGN(+) Macrophages Control the Induction of Transplantation Tolerance