2024-03-29T09:36:20Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/85582023-10-05T08:55:40Zcom_20.500.12105_2174com_20.500.12105_2051com_20.500.12105_2173col_20.500.12105_2175
00925njm 22002777a 4500
dc
Liu, Jingjing
author
Lončar, Ivona
author
Collée, J Margriet
author
Bolla, Manjeet K
author
Dennis, Joe
author
Michailidou, Kyriaki
author
Wang, Qin
author
Andrulis, Irene L
author
Barile, Monica
author
Beckmann, Matthias W
author
Behrens, Sabine
author
Benitez, Javier
author
Blomqvist, Carl
author
Boeckx, Bram
author
Bogdanova, Natalia V
author
Bojesen, Stig E
author
Brauch, Hiltrud
author
Brennan, Paul
author
Brenner, Hermann
author
Broeks, Annegien
author
Burwinkel, Barbara
author
Chang-Claude, Jenny
author
Chen, Shou-Tung
author
Chenevix-Trench, Georgia
author
Cheng, Ching Y
author
Choi, Ji-Yeob
author
Couch, Fergus J
author
Cox, Angela
author
Cross, Simon S
author
Cuk, Katarina
author
Czene, Kamila
author
Dörk, Thilo
author
Dos-Santos-Silva, Isabel
author
Fasching, Peter A
author
Figueroa, Jonine
author
Flyger, Henrik
author
García-Closas, Montserrat
author
Giles, Graham G
author
Glendon, Gord
author
Goldberg, Mark S
author
Gonzalez Neira, Anna
author
Guénel, Pascal
author
Haiman, Christopher A
author
Hamann, Ute
author
Hart, Steven N
author
Hartman, Mikael
author
Hatse, Sigrid
author
Hopper, John L
author
Ito, Hidemi
author
Jakubowska, Anna
author
Kabisch, Maria
author
Kang, Daehee
author
Kosma, Veli-Matti
author
Kristensen, Vessela N
author
Le Marchand, Loic
author
Lee, Eunjung
author
Li, Jingmei
author
Lophatananon, Artitaya
author
Jan Lubinski, null
author
Mannermaa, Arto
author
Matsuo, Keitaro
author
Milne, Roger L
author
Neuhausen, Susan L
author
Nevanlinna, Heli
author
Orr, Nick
author
Perez, Jose I A
author
Peto, Julian
author
Putti, Thomas C
author
Pylkäs, Katri
author
Radice, Paolo
author
Sangrajrang, Suleeporn
author
Sawyer, Elinor J
author
Schmidt, Marjanka K
author
Schneeweiss, Andreas
author
Shen, Chen-Yang
author
Shrubsole, Martha J
author
Shu, Xiao-Ou
author
Simard, Jacques
author
Southey, Melissa C
author
Swerdlow, Anthony
author
Teo, Soo H
author
Tessier, Daniel C
author
Thanasitthichai, Somchai
author
Tomlinson, Ian
author
Torres, Diana
author
Truong, Thérèse
author
Tseng, Chiu-Chen
author
Vachon, Celine
author
Winqvist, Robert
author
Wu, Anna H
author
Yannoukakos, Drakoulis
author
Zheng, Wei
author
Hall, Per
author
Dunning, Alison M
author
Easton, Douglas F
author
Hooning, Maartje J
author
van den Ouweland, Ans M W
author
Martens, John W M
author
Hollestelle, Antoinette
author
2016
NBS1, also known as NBN, plays an important role in maintaining genomic stability. Interestingly, rs2735383 G > C, located in a microRNA binding site in the 3'-untranslated region (UTR) of NBS1, was shown to be associated with increased susceptibility to lung and colorectal cancer. However, the relation between rs2735383 and susceptibility to breast cancer is not yet clear. Therefore, we genotyped rs2735383 in 1,170 familial non-BRCA1/2 breast cancer cases and 1,077 controls using PCR-based restriction fragment length polymorphism (RFLP-PCR) analysis, but found no association between rs2735383CC and breast cancer risk (OR = 1.214, 95% CI = 0.936-1.574, P = 0.144). Because we could not exclude a small effect size due to a limited sample size, we further analyzed imputed rs2735383 genotypes (r2 > 0.999) of 47,640 breast cancer cases and 46,656 controls from the Breast Cancer Association Consortium (BCAC). However, rs2735383CC was not associated with overall breast cancer risk in European (OR = 1.014, 95% CI = 0.969-1.060, P = 0.556) nor in Asian women (OR = 0.998, 95% CI = 0.905-1.100, P = 0.961). Subgroup analyses by age, age at menarche, age at menopause, menopausal status, number of pregnancies, breast feeding, family history and receptor status also did not reveal a significant association. This study therefore does not support the involvement of the genotype at NBS1 rs2735383 in breast cancer susceptibility.
Sci Rep. 2016 ;6:36874
2045-2322
http://hdl.handle.net/20.500.12105/8558
27845421
10.1038/srep36874
2045-2322
Scientific reports
rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk