2024-03-29T10:31:01Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/85532023-11-27T12:15:30Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2053com_20.500.12105_2052col_20.500.12105_16974col_20.500.12105_16970col_20.500.12105_16961col_20.500.12105_16959col_20.500.12105_2054
00925njm 22002777a 4500
dc
Castelló Pastor, Adela
author
Boldo, Elena
author
Amiano, Pilar
author
Castaño-Vinyals, Gemma
author
Aragones, Nuria
author
Gómez-Acebo, Inés
author
Peiró, Rosana
author
Jimenez-Moleon, Jose J.
author
Alguacil, Juan
author
Tardón, Adonina
author
Cecchini, Lluís
author
Lope Carvajal, Virginia
author
Dierssen-Sotos, Trinidad
author
Mengual, Lourdes
author
Kogevinas, Manolis
author
Pollan-Santamaria, Marina
author
Perez-Gomez, Beatriz
author
2018
PURPOSE: We explored the association of the previously described Western, prudent and Mediterranean dietary patterns with prostate cancer risk by tumor aggressiveness and extension. MATERIALS AND METHODS: MCC-Spain (Multicase-Control Study on Common Tumors in Spain) is a population based, multicase-control study that was done in 7 Spanish provinces between September 2008 and December 2013. It collected anthropometric, epidemiological and dietary information on 754 histologically confirmed incident cases of prostate cancer and 1,277 controls 38 to 85 years old. Three previously identified dietary patterns, including Western, prudent and Mediterranean, were reconstructed using MCC-Spain data. The association of each pattern with prostate cancer risk was assessed by logistic regression models with random, province specific intercepts. Risk according to tumor aggressiveness (Gleason score 6 vs greater than 6) and extension (cT1-cT2a vs cT2b-cT4) was evaluated by multinomial regression models. RESULTS: High adherence to a Mediterranean dietary pattern rich not only in fruits and vegetables but also in fish, legumes and olive oil was specifically associated with a lower risk of Gleason score greater than 6 prostate cancer (quartile 3 vs 1 relative RR 0.66, 95% CI 0.46-0.96 and quartile 4 vs 1 relative RR 0.68, 95% CI 0.46-1.01, p-trend = 0.023) or with higher clinical stage (cT2b-T4 quartile 4 vs 1 relative RR 0.49, 95% CI 0.25-0.96, p-trend = 0.024). This association was not observed with the prudent pattern, which combines vegetables and fruits with low fat dairy products, whole grains and juices. The Western pattern did not show any association with prostate cancer risk. CONCLUSIONS: Nutritional recommendations for prostate cancer prevention should consider whole dietary patterns instead of individual foods. We found important differences between the Mediterranean dietary pattern, which was associated with a lower risk of aggressive prostate cancer, and Western and prudent dietary patterns, which had no relationship with prostate cancer risk.
J Urol. 2018 Feb;199(2):430-437. doi: 10.1016/j.juro.2017.08.087. Epub 2017 Aug 23
0022-5347
http://hdl.handle.net/20.500.12105/8553
28842246
10.1016/j.juro.2017.08.087
1527-3792
The Journal of urology
Mediterranean
diet
prevention & control
principal component analysis
prostatic neoplasms
risk
Mediterranean Dietary Pattern is Associated with Low Risk of Aggressive Prostate Cancer: MCC-Spain Study