2024-03-29T12:11:42Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/85082022-10-10T12:04:06Zcom_20.500.12105_2174com_20.500.12105_2051com_20.500.12105_2173col_20.500.12105_2175
00925njm 22002777a 4500
dc
Muñoz-Lorente, Miguel A
author
Cano-Martin, Alba C
author
Blasco , MA
author
2019-10-17
Short telomeres trigger age-related pathologies and shorter lifespans in mice and humans. In the past, we generated mouse embryonic (ES) cells with longer telomeres than normal (hyper-long telomeres) in the absence of genetic manipulations, which contributed to all mouse tissues. To address whether hyper-long telomeres have deleterious effects, we generated mice in which 100% of their cells are derived from hyper-long telomere ES cells. We observe that these mice have longer telomeres and less DNA damage with aging. Hyper-long telomere mice are lean and show low cholesterol and LDL levels, as well as improved glucose and insulin tolerance. Hyper-long telomere mice also have less incidence of cancer and an increased longevity. These findings demonstrate that longer telomeres than normal in a given species are not deleterious but instead, show beneficial effects.
Nat Commun. 2019;10(1):4723.
2041-1723
http://hdl.handle.net/20.500.12105/8508
31624261
10.1038/s41467-019-12664-x
2041-1723
Nature communications
Mice with hyper-long telomeres show less metabolic aging and longer lifespans