2024-03-28T09:58:37Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/83532022-11-10T11:04:37Zcom_20.500.12105_2145com_20.500.12105_2051com_20.500.12105_2144col_20.500.12105_2146
00925njm 22002777a 4500
dc
Lopez-Melgar, Beatriz
author
Fernandez-Friera, Leticia
author
Oliva, Belen
author
Garcia-Ruiz, Jose M
author
Peñalvo, Jose L
author
Gomez-Talavera, Sandra
author
Sanchez-Gonzalez, Javier
author
Mendiguren, Jose M
author
Ibáñez, Borja
author
Fernandez-Ortiz, Antonio
author
Sanz, Javier
author
Fuster, Valentin
author
2017-07
BACKGROUND: Detection of subclinical atherosclerosis improves risk prediction beyond cardiovascular risk factors (CVRFs) and risk scores, but quantification of plaque burden may improve it further. Novel 3-dimensional vascular ultrasound (3DVUS) provides accurate volumetric quantification of plaque burden. OBJECTIVES: The authors evaluated associations between 3DVUS-based plaque burden and CVRFs and explored potential added value over simple plaque detection. METHODS: The authors included 3,860 (92.2%) PESA (Progression of Early Subclinical Atherosclerosis) study participants (age 45.8 ± 4.3 years; 63% men). Bilateral carotid and femoral territories were explored by 3DVUS to determine the number of plaques and territories affected, and to quantify global plaque burden defined as the sum of all plaque volumes. Linear regression and proportional odds models were used to evaluate associations of plaque burden with CVRFs and estimated 10-year cardiovascular risk. RESULTS: Plaque burden was higher in men (63.4 mm3 [interquartile range (IQR): 23.8 to 144.8 mm3] vs. 25.7 mm3 [IQR: 11.5 to 61.6 mm3] in women; p < 0.001), in the femoral territory (64 mm3 [IQR: 27.6 to 140.5 mm3] vs. 23.1 mm3 [IQR: 9.9 to 48.7 mm3] in the carotid territory; p < 0.001), and with increasing age (p < 0.001). Age, sex, smoking, and dyslipidemia were more strongly associated with femoral than with carotid disease burden, whereas hypertension and diabetes showed no territorial differences. Plaque burden was directly associated with estimated cardiovascular risk independently of the number of plaques or territories affected (p < 0.01). CONCLUSIONS: 3DVUS quantifies higher plaque burden in men, in the femoral territory, and with increasing age during midlife. Plaque burden correlates strongly with CVRFs, especially at the femoral level, and reflects estimated cardiovascular risk more closely than plaque detection alone. (Progression of Early Subclinical Atherosclerosis [PESA] Study; NCT01410318).
J Am Coll Cardiol. 2017; 70(3):301-313
0735-1097
http://hdl.handle.net/20.500.12105/8353
28705310
10.1016/j.jacc.2017.05.033
1558-3597
Journal of the American College of Cardiology
3-dimensional ultrasound
Carotid plaque
Femoral plaque
Plaque volume
Subclinical atherosclerosis
Subclinical Atherosclerosis Burden by 3D Ultrasound in Mid-Life: The PESA Study