2024-03-28T21:50:46Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/82062023-08-31T07:29:41Zcom_20.500.12105_2174com_20.500.12105_2051com_20.500.12105_2173col_20.500.12105_2175
00925njm 22002777a 4500
dc
Tapial, Sandra
author
Olmedillas-López, Susana
author
Rueda, Daniel
author
Arriba, María
author
García, Juan L
author
Vivas, Alfredo
author
Pérez, Jessica
author
Pena-Couso, Laura
author
Olivera, Rocío
author
Rodríguez, Yolanda
author
García-Arranz, Mariano
author
García-Olmo, Damián
author
González-Sarmiento, Rogelio
author
Urioste, Miguel
author
Goel, Ajay
author
Perea, José
author
2019-07-19
Colorectal cancer (CRC) with CpG island methylator phenotype (CIMP) is recognized as a subgroup of CRC that shows association with particular genetic defects and patient outcomes. We analyzed CIMP status of 229 individuals with CRC using an eight-marker panel (CACNA1G, CDKN2A, CRABP1, IGF2, MLH1, NEUROG1, RUNX3 and SOCS1); CIMP-(+) tumors were defined as having ≥ 5 methylated markers. Patients were divided into individuals who developed a "unique" CRC, which were subclassified into early-onset CRC (EOCRC) and late-onset CRC (LOCRC), and patients with multiple primary CRCs subclassified into synchronous CRC (SCRC) and metachronous CRC (MCRC). We found 9 (15.2%) CIMP-(+) EOCRC patients related with the proximal colon (p = 0.008), and 19 (26.8%) CIMP-(+) LOCRC patients associated with tumor differentiation (p = 0.045), MSI status (p = 0.021) and BRAF mutation (p = 0.001). Thirty-five (64.8%) SCRC patients had at least one CIMP-(+) tumor and 20 (44.4%) MCRC patients presented their first tumor as CIMP-(+). Thirty-nine (72.2%) SCRC patients showed concordant CIMP status in their simultaneous tumors. The differences in CIMP-(+) frequency between groups may reflect the importance of taking into account several criteria for the development of multiple primary neoplasms. Additionally, the concordance between synchronous tumors suggests CIMP status is generally maintained in SCRC patients.
Sci Rep. 2019 ;9(1):10516.
2045-2322
http://hdl.handle.net/20.500.12105/8206
31324877
10.1038/s41598-019-47014-w
2045-2322
Scientific reports
ISLAND METHYLATOR PHENOTYPE
MARKERS
MICROSATELLITE INSTABILITY
CHROMOSOMAL INSTABILITY
FIELD CANCERIZATION
BRAF MUTATION
COLON
PATHWAY
CLASSIFICATION
THERAPY
Cimp-Positive Status is More Representative in Multiple Colorectal Cancers than in Unique Primary Colorectal Cancers