2024-03-29T10:01:42Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/79672023-10-11T10:33:49Zcom_20.500.12105_2145com_20.500.12105_2051com_20.500.12105_2144col_20.500.12105_2146
00925njm 22002777a 4500
dc
del Campo, Lara
author
Hamczyk, Magda R.
author
Andres, Vicente
author
Martinez-Gonzalez, Jose
author
Rodriguez, Cristina
author
2018-06
Aging is the main risk factor for cardiovascular disease (CVD). The increased prevalence of CVD is partly due to the global increase in life expectancy. In this context, it is essential to identify the mechanisms by which aging induces CVD, with the ultimate aim of reducing its incidence. Both atherosclerosis and heart failure significantly contribute to age-associated CVD morbidity and mortality. Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder caused by the synthesis of progerin, which is noted for accelerated aging and CVD. This mutant form of prelamin A induces generalised atherosclerosis, vascular calcification, and cardiac electrophysiological abnormalities, leading to premature aging and death, mainly due to myocardial infarction and stroke. This review discusses the main vascular structural and functional abnormalities during physiological and premature aging, as well as the mechanisms involved in the exacerbated CVD and accelerated aging induced by the accumulation of progerin and prelamin A. Both proteins are expressed in non-HGPS individuals, and physiological aging shares many features of progeria. Research into HGPS could therefore shed light on novel mechanisms involved in the physiological aging of the cardiovascular system.
Clin Investig Arterioscler. 2018; 30(3):120-32
02149168
http://hdl.handle.net/20.500.12105/7967
29602596
10.1016/j.arteri.2017.12.007
1578-1879
Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis
Aterosclerosis
Atherosclerosis
Calcificación vascular
Cardiovascular disease
Enfermedad cardiovascular
Prelamin A/lamin A
Prelamina A/lamina A
Progerin
Progerina
Vascular calcification
Mechanisms of vascular aging: What can we learn from Hutchinson-Gilford progeria syndrome?