2024-03-28T10:25:02Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/77702023-10-09T09:23:06Zcom_20.500.12105_2145com_20.500.12105_2051com_20.500.12105_2144col_20.500.12105_2146
00925njm 22002777a 4500
dc
Cogliati, Sara
author
Frezza, Christian
author
Soriano, Maria Eugenia
author
Varanita, Tatiana
author
Quintana-Cabrera, Ruben
author
Corrado, Mauro
author
Cipolat, Sara
author
Costa, Veronica
author
Casarin, Alberto
author
Gomes, Ligia C
author
Perales-Clemente, Ester
author
Salviati, Leonardo
author
Fernandez-Silva, Patricio
author
Enriquez, Jose Antonio
author
Scorrano, Luca
author
2013-09
Respiratory chain complexes assemble into functional quaternary structures called supercomplexes (RCS) within the folds of the inner mitochondrial membrane, or cristae. Here, we investigate the relationship between respiratory function and mitochondrial ultrastructure and provide evidence that cristae shape determines the assembly and stability of RCS and hence mitochondrial respiratory efficiency. Genetic and apoptotic manipulations of cristae structure affect assembly and activity of RCS in vitro and in vivo, independently of changes to mitochondrial protein synthesis or apoptotic outer mitochondrial membrane permeabilization. We demonstrate that, accordingly, the efficiency of mitochondria-dependent cell growth depends on cristae shape. Thus, RCS assembly emerges as a link between membrane morphology and function.
Cell. 2013; 155(1):160-71
0092-8674
http://hdl.handle.net/20.500.12105/7770
24055366
10.1016/j.cell.2013.08.032
1097-4172
Cell
Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency