2024-03-29T14:17:54Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/73462023-08-31T06:44:13Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2053com_20.500.12105_2052col_20.500.12105_16989col_20.500.12105_16978col_20.500.12105_2054
00925njm 22002777a 4500
dc
Lope Carvajal, Virginia
author
Martín, Miguel
author
Castelló Pastor, Adela
author
Ruiz, Amparo
author
Casas, Ana Mª
author
Baena-Cañada, José Manuel
author
Antolín, Silvia
author
Ramos-Vázquez, Manuel
author
García-Sáenz, José Ángel
author
Muñoz, Montserrat
author
Lluch, Ana
author
de Juan-Ferré, Ana
author
Jara, Carlos
author
Sánchez-Rovira, Pedro
author
Antón, Antonio
author
Chacón, José Ignacio
author
Arcusa, Angels
author
Jimeno, Mª Angeles
author
Bezares, Susana
author
Vioque, Jesus
author
Carrasco, Eva
author
Perez-Gomez, Beatriz
author
Pollan-Santamaria, Marina
author
2019-03-07
This study analyzes the association of excessive energy intake and caloric restriction with breast cancer (BC) risk taking into account the individual energy needs of Spanish women. We conducted a multicenter matched case-control study where 973 pairs completed lifestyle and food frequency questionnaires. Expected caloric intake was predicted from a linear regression model in controls, including calories consumed as dependent variable, basal metabolic rate as an offset and physical activity as explanatory. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. The association with BC risk, overall and by pathologic subtype, was evaluated using conditional and multinomial logistic regression models. While premenopausal women that consumed few calories (>20% below predicted) had lower BC risk (OR = 0.36; 95% CI = 0.21-0.63), postmenopausal women with an excessive intake (≥40% above predicted) showed an increased risk (OR = 2.81; 95% CI = 1.65-4.79). For every 20% increase in relative (observed/predicted) caloric intake the risk of hormone receptor positive (p-trend < 0.001) and HER2+ (p-trend = 0.015) tumours increased 13%, being this figure 7% for triple negative tumours. While high energy intake increases BC risk, caloric restriction could be protective. Moderate caloric restriction, in combination with regular physical activity, could be a good strategy for BC prevention.
Sci Rep. 2019 Mar 7;9(1):3904.
2045-2322
http://hdl.handle.net/20.500.12105/7346
30846706
10.1038/s41598-019-39346-4
Scientific reports
Overeating, caloric restriction and breast cancer risk by pathologic subtype: the EPIGEICAM study