2024-03-28T17:53:17Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/69362023-08-31T07:14:36Zcom_20.500.12105_2053com_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_2054
00925njm 22002777a 4500
dc
Rayman, Margaret P
author
Blundell-Pound, Gabrielle
author
Pastor-Barriuso, Roberto
author
Guallar, Eliseo
author
Steinbrenner, Holger
author
Stranges, Saverio
author
2012-09
BACKGROUND: Evidence that selenium affects the risk of type-2 diabetes is conflicting, with observational studies and a few randomized trials showing both lower and higher risk linked to the level of selenium intake and status. We investigated the effect of selenium supplementation on the risk of type-2 diabetes in a population of relatively low selenium status as part of the UK PRECISE (PREvention of Cancer by Intervention with SElenium) pilot study. Plasma adiponectin concentration, a recognised independent predictor of type-2 diabetes risk and known to be correlated with circulating selenoprotein P, was the biomarker chosen. METHODS: In a randomized, double-blind, placebo-controlled trial, five hundred and one elderly volunteers were randomly assigned to a six-month intervention with 100, 200 or 300 µg selenium/d as high-selenium or placebo yeast. Adiponectin concentration was measured by ELISA at baseline and after six months of treatment in 473 participants with one or both plasma samples available. RESULTS: Mean (SD) plasma selenium concentration was 88.5 ng/g (19.1) at baseline and increased significantly in the selenium-treatment groups. In baseline cross-sectional analyses, the fully adjusted geometric mean of plasma adiponectin was 14% lower (95% CI, 0-27%) in the highest than in the lowest quartile of plasma selenium (P for linear trend = 0.04). In analyses across randomized groups, however, selenium supplementation had no effect on adiponectin levels after six months of treatment (P = 0.96). CONCLUSIONS: These findings are reassuring as they did not show a diabetogenic effect of a six-month supplementation with selenium in this sample of elderly individuals of relatively low selenium status.
PLoS One. 2012;7(9):e45269
1932-6203
http://hdl.handle.net/20.500.12105/6936
23028897
10.1371/journal.pone.0045269
1932-6203
PloS one
A randomized trial of selenium supplementation and risk of type-2 diabetes, as assessed by plasma adiponectin